王克剑，研究员，博士生导师，1983年12月生，江苏盐城人。中国农业科学院水稻染色体工程及基因组编辑创新团队，首席科学家；中国水稻研究所基因资源挖掘与利用研究室，课题组长。 2004年扬州大学农学学士；2009年中国科学院遗传与发育生物学研究所理学博士；2009-2013年就职于中国科学院遗传与发育生物学研究所，任助理研究员、副研究员；2013年至今，中国水稻研究所研究员。近年在国际SCI期刊上发表论文29篇，其中通讯作者论文8篇。先后主持国家自然科学基金2项、浙江省自然科学基金重点项目1项、国家973计划子课题1项；以学术骨干身份参加国家863计划1项；已获国家发明专利6项。 主要研究方向 水稻遗传重组机制及应用研究； 水稻基因组编辑及应用研究； 水稻基因资源挖掘及利用。 通讯作者论文 Hu, X#., Meng, X#., Liu, Q., Li, J*., and Wang K*.(2017). Increasing the efficiency of CRISPR-Cas9-VQR precise genome editing in rice. Plant Biotechnology Journal (DOI: 10.1111/pbi.12771) （最新IF=7.443，其中第一作者胡熙璕为专业硕士研究生；中文简介：http://www.caas.net.cn/xwzx/kyjz/283344.html） Hua, Y#., Wang, C#., Huang, J#., and Wang, K*. (2017). A simple and efficient method for CRISPR/Cas9 mutant screening. Journal of Genetics and Genomics（最新IF=4.051，中文简介：http://www.caas.net.cn/ysxw/kyjz/281001.shtml） Shen, L#., Hua, Y#., Fu, Y#., Li, J#., Liu, Q., Jiao, X., Xin, G., Wang, J., Wang, X., Yan, C*., and Wang, K*. (2017). Rapid generation of genetic diversity by multiplex CRISPR/Cas9 genome editing in rice. Science China Life Sciences (DOI: 10.1007/s11427-017-9008-8) （最新IF=2.781，基因编辑专刊约稿） Hu, X#., Wang, C#., Liu, Q., Fu, Y., and Wang, K*. (2017). Targeted mutagenesis in rice using CRISPR-Cpf1 system. Journal of Genetics and Genomics 44, 71-73. （最新IF=4.051，其中第一作者胡熙璕为专业硕士研究生；中文简介：http://www.caas.net.cn/ysxw/kyjz/277667.shtml） Hu, X#., Wang, C#., Fu, Y#., Liu, Q., Jiao, X., and Wang, K*. (2016). Expanding the Range of CRISPR/Cas9 Genome Editing in Rice. Molecular Plant, 9, 943-945. (当年IF=8.827，其中第一作者胡熙璕为专业硕士研究生；中文简介：http://www.caas.net.cn/ysxw/kyjz/268716.shtml) Shen, L#., Wang, C#., Fu, Y., Wang, J., Liu, Q., Zhang, X., Yan, C*., Qian, Q*., and Wang, K*. (2016). QTL editing confers opposing yield performance in different rice varieties. Journal of Integrative Plant Biology (DOI: 10.1111/jipb.12501) （当年IF=3.962，中文简介：http://www.caas.net.cn/ysxw/kyjz/275281.shtml） Wang, C#., Shen, L#., Fu, Y., Yan, C., Wang, K*. A Simple CRISPR/Cas9 System for Multiplex Genome Editing in Rice. Journal of Genetics and Genomics, 2015, 42:703-706. (当年IF=3.981，中文简介：http://www.caas.net.cn/ysxw/kyjz/262667.shtml) Wang, K*., Wang, C., Liu, Q., Fu, Y. Increasing the Genetic Recombination Frequency by Partial Loss of Function of the Synaptonemal Complex in Rice. Molecular Plant, 2015, 8: 1295-1298.（当年IF=7.142，中文简介：http://www.caas.net.cn/ysxw/kyjz/255650.shtml） 其它论文 Che, L#., Wang, K#（共同第一）., Tang, D., Liu, Q., Chen, X., Li, Y., Hu, Q., Shen, Y., Yu, H., Gu, M., et al.. OsHUS1 Facilitates Accurate Meiotic Recombination in Rice. PLoS Genetics, 2014, 10:e1004405.（当年IF=8.167） Wang, K (第一作者)., Wang, M., Tang, D., Shen, Y., Miao, C., Hu, Q., Lu, T., Cheng, Z.. The role of HEI10 in crossover formation in rice. PLoS Genetics, 2012, 8:e1002809.（当年IF=8.517） Wang, K (第一作者)., Wang, M., Tang, D., Shen, Y., Qin, B., Li, M., and Cheng, Z.. PAIR3, an axis-associated protein, is essential for the recruitment of recombination elements onto meiotic chromosomes in rice. Molecular Biology of the Cell, 2011, 22:12-19.（当年IF=4.942） Wang, K (第一作者)., Tang, D., Hong, L., Xu, W., Huang, J., Li, M., Gu, M., Xue, Y., Cheng, Z.. DEP and AFO regulate reproductive habit in rice. PLoS Genetics, 2010, 6:e1000818.（封面文章，当年IF=9.543） Wang, K (第一作者)., Tang, D., Wang, M., Lu J., Yu, H., Liu, J., Qian, B., Gong, Z., Wang, X., Chen, J., Gu, M., and Cheng, Z.. MER3 is required for normal meiotic crossover formation, but not for presynaptic alignment in rice. Journal of Cell Science, 2009, 122:2055-2063.（当年IF=6.144） Wang, M., Wang, K., Tang, D., Wei, C., Li, M., Shen, Y., Chi, Z., Gu, M., Cheng, Z.. The Central Element Protein ZEP1 of the Synaptonemal Complex Regulates the Number of Crossovers during Meiosis in Rice. The Plant Cell, 2010, 22:417-430.（当年IF=9.396） Hong, L., Tang, D., Zhu, K., Wang, K., Li, M., and Cheng, Z.. Somatic and Reproductive Cell Development in Rice Anther Is Regulated by a Putative Glutaredoxin. The Plant Cell, 2012, 24:577-588.（当年IF=9.251） Wang, M., Tang, D., Luo, Q., Jin, Y., Shen, Y., Wang, K., Cheng, Z.. BRK1, a Bub1-related kinase, is essential for generating proper tension between homologous kinetochores at metaphase I of rice meiosis. The Plant Cell, 2012, 24:4961-4973.（当年IF=9.251） Wu, X., Tang, D., Li, M., Wang, K., Cheng, Z.. Loose plant architecture 1, an INDETERMINATE domain protein involved in shoot gravitropism, regulates plant architecture in rice. Plant Physiology, 2013, 161:317-329.（当年IF=7.394） Luo, Q., Tang, D., Wang, M., Luo, W., Zhang, L., Qin, B., Shen, Y., Wang, K., Li, Y., Cheng, Z. The role of OsMSH5 in crossover formation during rice meiosis. Molecular Plant, 2013, 6:729-742.（当年IF=6.605） Ji, J., Tang D., Wang, M., Li, Y., Zhang L, Wang, K., Li, M., and Cheng, Z.. MRE11 is required for homologous synapsis and DSB processing in rice meiosis. Chromosoma, 2013, 122:363-376.（当年IF=3.260） Ji, J., Tang, D., Wang, K., Wang, M., Che, L., Li, M., Cheng, Z.. The role of OsCOM1 in homologous chromosome synapsis and recombination in rice meiosis. The Plant Journal, 2012, 72:18-30.（当年IF=6.582） Shen, Y., Tang, D., Wang, K., Wang, M., Huang, J., Luo, W., Luo, Q., Hong, L., Li, M., Cheng, Z.. The Role of ZIP4 in Homologous Chromosome Synapsis and Crossover Formation in Rice Meiosis. Journal of Cell Science, 2012, 125:2581-2591.（当年IF=5.877） Hong, L., Qian, Q., Tang, D., Wang, K., Li, M., and Cheng, Z.. A mutation in the rice chalcone isomerase gene causes the golden hull and internode 1 phenotype. Planta, 2012, 236:141-151.（当年IF=3.347） Hong, L., Tang, D., Shen, Y., Hu, Q., Wang, K., Li, M., Lu, T., and Cheng, Z.. MIL2 (MICROSPORELESS2) regulates early cell differentiation in the rice anther. New Phytologist, 2012, 196:402-413.（当年IF=6.736） Che, L., Tang, D., Wang, K., Wang, M., Zhu, K., Yu, H., Gu, M., and Cheng, Z.. OsAM1 is required for leptotene-zygotene transition in rice. Cell Research, 2011, 21:654-665.（当年IF=8.19） Shao, T., Tang, D., Wang, K., Wang, M., Che, L., Qin, B., Yu, H., Li, M., Gu, M., and Cheng, Z.. OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis. Plant Physiology, 2011, 156:1386-1396.（当年IF=6.535） Wang, M., Tang, D., Wang, K., Shen, Y., Qin, B., Miao, C., Li, M., and Cheng, Z.. OsSGO1 maintains synaptonemal complex stabilization in addition to protecting centromeric cohesion during rice meiosis. The Plant Journal, 2011, 67:583-594.（当年IF=6.160） Li, M., Tang, D., Wang, K., Wu, X., Lu, L., Yu, H., Gu, M., Yan, C., and Cheng, Z.. Mutations in the F-box gene LARGER PANICLE improve the panicle architecture and enhance the grain yield in rice. Plant Biotechnology Journal, 2011, 9:1002-1013.（当年IF=5.442） Qin, B., Tang, D., Huang, J., Li, M., Wu, X., Lu, L., Wang, K., Yu, H., Chen, J., Gu, M., and Cheng, Z.. Rice OsGL1-1 is involved in leaf cuticular wax and cuticle membrane. Molecular Plant, 2011, 4:985-995.（当年IF=5.546） Yu, H., Wang, M., Tang, D., Wang, K., Chen, F., Gong, Z., Gu, M., and Cheng, Z.. OsSPO11-1 is essential for both homologous chromosome pairing and crossover formation in rice. Chromosoma, 2010, 119:625-636.（当年IF=4.196）

研究方向

所在机构

中国水稻研究所

主要成就

近年在国际SCI期刊上发表论文29篇，其中通讯作者论文8篇。先后主持国家自然科学基金2项、浙江省自然科学基金重点项目1项、国家973计划子课题1项；以学术骨干身份参加国家863计划1项；已获国家发明专利6项。

教育背景

2004年扬州大学农学学士；2009年中国科学院遗传与发育生物学研究所理学博士

发文趋势