文献类型： 外文期刊
作者： Pan, Lianyun 1 ; Lu, Yan 1 ; Dai, Shen 1 ; Tang, Xiangyue 1 ; Xiong, Ligui 1 ; Liu, Zhonghua 1 ; Gong, Yushun 1 ;
作者机构： 1.Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredien, Changsha 410128, Peoples R China
2.Yunnan Acad Agr Sci, Tea Res Inst, Yunnan Key Lab Tea Sci, Menghai 666200, Peoples R China
3.Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Peoples R China
关键词： Fuzhuan brick tea; Cholesterol; Fat storage; Sterol regulatory element-binding protein
期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：7.0； 五年影响因子：8.3 ）
ISSN：
年卷期： 2023 年 12 卷 6 期
页码：
收录情况： SCI
摘要： Fuzhuan brick-tea (FZT) has long been consumed for its supposed weight loss and lipid-lowering benefits. In this study, we show that the regulation of fat storage in Caenorhabditis elegans from a water extract of FZT was affected by cholesterol levels. We found that FZT significantly decreased fat storage under normal cholesterol levels or in a cholesterol-free diet, while lipid accumulation was increased for a high cholesterol diet. Moreover, this mechanism may involve the conserved sterol regulatory element-binding protein (SREBP)/ mediator-15 (MDT-15) signaling pathway and the nuclear hormone receptor NHR-80. In addition, lipid synthesis-related genes inhibited by FZT were partially affected by a cholesterol-free diet. Thus, our findings suggested that the potential lipid-lowering effects of FZT may depend on the cholesterol level, which may help to improve the consumption of FZT. (c) 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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