文献类型： 外文期刊

作者： Zhang, Dongying ¹ ; Zhou, Qixing ³ ; Zhang, Zhen ³ ; Yang, Xiangxuan ³ ; Man, Jiaxu ⁴ ; Wang, Dongxue ³ ; Li, Xiaoyong ² ;

作者机构： 1.Yunnan Agr Univ, Coll Sci, Kunming 650201, Peoples R China

2.Hezhou Univ, Coll Food & Biol Engn, Hezhou 542899, Peoples R China

3.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China

4.Yunnan Acad Agr Sci, Inst Agr Prod Proc, Kunming 650201, Peoples R China

关键词： Flemingia philippinensis; improve inflammation; network pharmacology; molecular docking

期刊名称：NUTRIENTS （ 影响因子：4.8； 五年影响因子：5.8 ）

ISSN：

年卷期： 2024 年 16 卷 12 期

页码：

收录情况： SCI

摘要： Flemingia philippinensis, a polyphenol-rich plant, holds potential for improving inflammation, but its mechanisms are not well understood. Therefore, this study employed network pharmacology and molecular docking to explore the mechanism by which Flemingia philippinensis ameliorates inflammation. In this study, 29 kinds of active ingredients were obtained via data mining. Five main active components were screened out for improving inflammation, which were flemichin D, naringenin, chrysophanol, genistein and orobol. In total, 52 core targets were identified, including AKT serine/threonine kinase 1 (AKT1), tumor necrosis factor (TNF), B-cell lymphoma-2 (BCL2), serum albumin (ALB), and estrogen receptor 1 (ESR1). Gene ontology (GO) enrichment analysis identified 2331 entries related to biological processes, 98 entries associated with cellular components, and 203 entries linked to molecular functions. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis yielded 149 pathways, including those involved in EGFR tyrosine kinase inhibitor resistance, endocrine resistance, and the PI3K-Akt signaling pathway. Molecular docking results showed strong binding effects between the main active components and the core targets, with binding energies less than -5 kcal/mol. In summary, this study preliminarily elucidated the underlying mechanisms by which Flemingia philippinensis, through a multi-component, multi-target, and multi-pathway approach, ameliorates inflammation. This provides a theoretical foundation for the subsequent application of Flemingia philippinensis in inflammation amelioration.