The Traditional Usages, Chemical Components and Pharmacological Activities of Wolfiporia cocos: A Review
文献类型： 外文期刊
作者： Li, Lian 1 ; Zuo, Zhi-Tian 1 ; Wang, Yuan-Zhong 1 ;
作者机构： 1.Yunnan Acad Agr Sci, Med Plants Res Inst, Kunming 650200, Yunnan, Peoples R China
2.Yunnan Univ Chinese Med, Coll Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China
关键词： Wolfiporia cocos; Pharmacological Activities; Chemical Components; Structure-Activity Relationship (SAR); Review
期刊名称：AMERICAN JOURNAL OF CHINESE MEDICINE （ 影响因子：6.005； 五年影响因子：5.05 ）
ISSN： 0192-415X
年卷期： 2022 年 50 卷 02 期
页码：
收录情况： SCI
摘要： As an endemic species,Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb. is widely distributed, such as in China, Korea, Japan, and North America, which have had a dual-purpose resource for medicines and food for over 2000 years. The applications of W. cocos were used to treat diseases including edema, insomnia, spleen deficiency, and vomiting. What's more, there have been wide uses of such edible fungi as a function food or dietary supplement recently. Up until now, 166 kinds of chemical components have been isolated and identified from W. cocos including triterpenes, polysaccharides, sterols, diterpenes, and others. Modern pharmacological studies showed that the components hold a wide range of pharmacological activities both in vitro and in vivo, such as antitumor, anti-inflammatory, antibacterial, anti-oxidant, and antidepressant activities. In addition, present results showed that the mechanisms of pharmacological activities were closely related to chemical structures, molecular signaling paths and the expression of relate proteins for polysaccharides and triterpenes. For further in-depth studies on this fungus based on the recent research status, this review provided some perspectives and systematic summaries of W. cocos in traditional uses, chemical components, pharmacological activities, separation and analysis technologies, and structure-activity relationships.
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