Truffle protein and its derived peptides exhibit sleep-promoting effects via regulation of lysosomal autophagy, neurological activity, tyrosine metabolism, and fatty acid elongation
文献类型： 外文期刊
作者： Li, Yujing 1 ; Liang, Yuxuan 2 ; Peng, Chunxiu 5 ; Gong, Jiashun 1 ;
作者机构： 1.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Yunnan, Peoples R China
2.Shenzhen Univ, Sch Biomed Engn, Natl Reg Key Technol Engn Lab Med Ultrasound, Guangdong Key Lab Biomed Measurements & Ultrasound, Shenzhen 518060, Peoples R China
3.Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Food Nutr & Hlth, Shenzhen 518060, Peoples R China
4.Shenzhen Univ, Inst Innovat Dev Food Ind, Shenzhen 518060, Peoples R China
5.Yunnan Agr Univ, Coll Hort & Landscape, Kunming 650201, Yunnan, Peoples R China
6.Yunnan Acad Agr Sci, Agroprod Proc Res Inst, Kunming 650221, Yunnan, Peoples R China
关键词： Truffle protein; Sleep; Drosophila melanogaster; Transcriptomic; RNAi
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2024 年 281 卷
页码：
收录情况： SCI
摘要： Black truffle (Tuber sinense) is a famous luxurious mushroom with abundant protein resources. Nevertheless, until now, no single study has explored the potential function of black truffle protein in any animal models. Thus, this study investigated the sleep-promoting effects of truffle albumin (TA) and its hydrolysate (TAH). Then, two novel sleep-enhancing peptides were explored from TAH. Our results showed that TA and TAH significantly prolonged the total sleep time and improved sleep quality of insomnia Drosophila. Additionally, two novel peptides YLDLAPL and YLRPEGDW with strong sleep-enhancing activity were explored by virtual screening and Drosophila with transgenic RNA interference (RNAi) technology. Finally, the transcriptomics analysis investigated potential mechanisms of sleep-enhancing effects in Drosophila: (1) regulation of the autophagic activity by altering the lysosomal protein; (2) up-regulation the genes in the pathway of neuroactive ligand-receptor interaction and promotion the function of neurons; (3) promotion the conversion of tyrosine into neurotransmitters; (4) regulation substrate feeding into the tricarboxylic acid (TCA) cycle and promotion free radical scavenging in neuronal cells; (5) promotion the fatty acid elongation and preservation neuronal cells avoid from oxidation.
- 相关文献
作者其他论文 更多>>
-
Konjac glucomannan: A key ingredient for controlling fibrous structure formation in walnut protein and wheat gluten meat analogues during the high-moisture extrusion process
作者：Lei, Shuwen;Zhao, Chunyan;Zhao, Hong;Fu, Xiaoping;Gong, Jiashun;Gong, Jiashun;Peng, Chunxiu;Miao, Yue
关键词：Walnut protein; Wheat gluten; Konjac glucomannan; Meat analogues; Fibrous structure formation; High-moisture extrusion process
-
Theabrownin remodels the circadian rhythm disorder of intestinal microbiota induced by a high-fat diet to alleviate obesity in mice
作者：Zhao, Chunyan;Lei, Shuwen;Zhao, Hong;Li, Zelin;Miao, Yue;Gong, Jiashun;Li, Zelin;Gong, Jiashun;Peng, Chunxiu;Miao, Yue
关键词：
-
Quality characteristics and fibrous structure formation mechanism of walnut protein and wheat gluten meat analogues during high-moisture extrusion cooking process
作者：Lei, Shuwen;Zhao, Chunyan;Zhao, Hong;Liu, Zhichen;Zhang, Yuzhuang;Zhao, Lei;Gong, Jiashun;Gong, Jiashun;Peng, Chunxiu;Miao, Yue
关键词：Walnut protein; Wheat gluten; Meat analogues; High-moisture extrusion process; Fibrous structure formation mechanism
-
Theabrownin from Pu-erh tea attenuated high-fat diet-induced metabolic syndrome in rat by regulating microRNA and affecting gut microbiota
作者：Shan, Bo;Zhao, Chunyan;Miao, Yue;Lei, Shuwen;Zhao, Lei;Gong, Jiashun;Wang, Qiuping;Peng, Chunxiu;Zhao, Lei;Jia, Man;Pan, Shukang;Gong, Jiashun
关键词：Pu-erh tea; Theabrownin; miRNA; Metabolic syndrome; High-fat diet; Gut microbiota
-
Novel insights related to soil microplastic abundance and vegetable microplastic contamination
作者：Liu, Xingyong;Gong, Jiashun;Liu, Xingyong;Shao, Jinliang;Peng, Chunxiu;Gong, Jiashun
关键词：Microplastics abundances; Farmland soil; Vegetable; Accumulation; Correlation Analysis
-
Microbial-driven mechanisms of arsenic methylation during Chinese rice wine fermentation
作者：Liu, Yanfang;Fan, Bei;Li, Lin;Xiong, Yangyang;Wang, Xinrui;Huang, Yatao;Wang, Fengzhong;Liu, Yanfang;Fan, Bei;Li, Lin;Xiong, Yangyang;Wang, Xinrui;Huang, Yatao;Wang, Fengzhong;Fan, Bei;Huang, Yatao;Wang, Fengzhong;Liu, Yanfang;Gong, Jiashun;Gong, Jiashun
关键词：Chinese rice wine; Total arsenic; Arsenic species; Arsenic methylation; Microorganisms; Fermentation
-
Effects of the mixed fermentation of apples and yeast on the sensory evaluation, physicochemical composition and flavor of coffee beans
作者：He, Zejuan;Cao, Liangjun;Tan, Chao;Zhao, Linfen;Zhu, Chao;Gong, Jiashun;Zhou, Yong
关键词：Coffee; Fermentation; Sensory evaluation; Flavour; Physicochemical composition
