文献类型： 外文期刊
作者： Liao, Rongqiang 1 ; Liu, Ying 1 ; Lv, Pin 2 ; Wu, Di 1 ; Xu, Meiling 1 ; Zheng, Xiaoyuan 1 ;
作者机构： 1.Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Pharm Dept, Chongqing, Peoples R China
2.Yunnan Acad Agr Sci, Ind Crop Res Inst, Kunming, Yunnan, Peoples R China
3.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China
关键词： Cyclodextrin; poly(ε -lysine); drug carrier; scutellarin
期刊名称：DRUG DELIVERY （ 2020影响因子：6.419； 五年影响因子：6.169 ）
ISSN： 1071-7544
年卷期： 2020 年 27 卷 1 期
收录情况： SCI
摘要： A novel beta-cyclodextrin pendant polymer (epsilon-PL-CD), composed of poly(epsilon-lysine) (epsilon-PL) main chain and glycine-beta-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The epsilon-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCU:epsilon-PL-CD were researched in both solution and solid state by means of photoluminescence spectroscopy, H-1 and 2D NMR, X-Ray powder diffraction (XRPD), thermal gravimetric analysis, Particle size and Zeta potential. The solubility test indicated that the solubilizing ability of SCU:epsilon-PL-CD was significantly improved compared with SCU:beta-CD and free SCU. Besides, in vitro cell experiment, it was found that SCU:epsilon-PL-CD has a strong inhibitory effect on the growth and invasion of tumor cells. The present study provides useful information for epsilon-PL-CD as a drug carrier material.
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