文献类型： 外文期刊

作者： Sun, Cheng ¹ ; Huang, Jiaxing ¹ ; Wang, Yun ² ; Zhao, Xiaomeng ¹ ; Su, Long ¹ ; Thomas, Gregg W. C. ³ ; Zhao, Mengya ⁴ ;

作者机构： 1.Chinese Acad Agr Sci, Inst Apicultural Res, Beijing, Peoples R China

2.Chongqing Univ, Sch Life Sci, Chongqing, Peoples R China

3.Univ Montana, Div Biol Sci, Missoula, MT 59812 USA

4.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan, Peoples R China

5.Fujian Agr & Forestry Univ, Fujian Prov Key Lab Haixia Appl Plant Syst Biol, Fuzhou, Peoples R China

6.MIT, Comp Sci & Artificial Intelligence Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA

7.Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

8.Univ Bari, Inst Atmospher Pollut Res, Italian Natl Res Council, Dept Phys, Bari, Italy

9.Virginia Polytech & State Univ, Dept Entomol, Blacksburg, VA USA

10.Tomsk State Univ, Dept Cytol & Genet, Tomsk, Russia

11.Univ Hohenheim, Inst Anim Sci, Dept Livestock Populat Genom, Stuttgart, Germany

12.Univ Calif Santa Cruz, UC Santa Cruz Genom Inst, Santa Cruz, CA 95064 USA

13.Deutsch Krebsforschungszentrum, Heidelberg, Germany

14.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr,Minist Agr,Genom, Shenzhen, Peoples R China

15.BGI Shenzhen, BGI Genom, Shenzhen, Peoples R China

16.Chinese Acad Sci, China Natl Ctr Bioinformat, Beijing, Peoples R China

17.Chinese Acad Sci, Beijing Inst Genom, Beijing, Peoples R China

18.Jiujiang Univ, Coll Pharm & Life Sci, Jiujiang, Peoples R China

19.Univ Lausanne, Dept Ecol & Evolut, Lausanne, Switzerland

20.Swiss Inst Bioinformat, Lausanne, Switzerland

21.Univ Illinois, Dept Entomol, Champaign, IL USA

22.Univ Calif Davis, Genome Ctr, Dept Med Microbiol & Immunol, Davis, CA 95616 USA

23.Univ Calif Davis, MIND Inst, Davis, CA 95616 USA

24.Yunnan Acad Agr Sci, Inst Sericultural & Apiculture, Mengzi, Peoples R China

25.Colorado State Univ, Dept Biol, Ft Collins, CO 80523 USA

26.Univ Liverpool, Inst Integrat Biol, Dept Ecol Evolut & Behav, Liverpool, Merseyside, England

27.Illinois State Univ, Sch Biol Sci, Normal, IL 61761 USA

28.Indiana Univ, Dept Biol, Bloomington, IN USA

29.Indiana Univ, Dept Comp Sci, Bloomington, IN 47405 USA

30.Reed Coll, Dept Biol, Portland, OR 97202 USA

31.Nat Hist Museum, Dept Life Sci, London, England

关键词： Bombus; insect diversity; genome assembly; genome evolution; gene family evolution

期刊名称：MOLECULAR BIOLOGY AND EVOLUTION （ 影响因子：11.062； 五年影响因子：13.401 ）

ISSN： 0737-4038

年卷期： 2021 年 38 卷 2 期

页码：

收录情况： SCI

摘要： Bumblebees are a diverse group of globally important pollinators in natural ecosystems and for agricultural food production. With both eusocial and solitary life-cycle phases, and some social parasite species, they are especially interesting models to understand social evolution, behavior, and ecology. Reports of many species in decline point to pathogen transmission, habitat loss, pesticide usage, and global climate change, as interconnected causes. These threats to bumblebee diversity make our reliance on a handful of well-studied species for agricultural pollination particularly precarious. To broadly sample bumblebee genomic and phenotypic diversity, we de novo sequenced and assembled the genomes of 17 species, representing all 15 subgenera, producing the first genus-wide quantification of genetic and genomic variation potentially underlying key ecological and behavioral traits. The species phylogeny resolves subgenera relationships, whereas incomplete lineage sorting likely drives high levels of gene tree discordance. Five chromosome-level assemblies show a stable 18-chromosome karyotype, with major rearrangements creating 25 chromosomes in social parasites. Differential transposable element activity drives changes in genome sizes, with putative domestications of repetitive sequences influencing gene coding and regulatory potential. Dynamically evolving gene families and signatures of positive selection point to genus-wide variation in processes linked to foraging, diet and metabolism, immunity and detoxification, as well as adaptations for life at high altitudes. Our study reveals how bumblebee genes and genomes have evolved across the Bombus phylogeny and identifies variations potentially linked to key ecological and behavioral traits of these important pollinators.