文献类型： 外文期刊
作者： Zhang, Dongjing 1 ; Lv, Pin 2 ; Zhou, Cheng 1 ; Zhao, Yulin 3 ; Liao, Xiali 1 ; Yang, Bo 1 ;
作者机构： 1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China
2.Yunnan Acad Agr Sci, Ind Crop Res Inst, Kunming 650205, Yunnan, Peoples R China
3.Kunming Univ Sci & Technol, Fac Chem Engn, Kunming 650500, Yunnan, Peoples R China
关键词： Cyclodextrin-based delivery system; Cancer treatment; Chemotherapy drugs; Genetic therapeutic agents; Targeting; Intelligent; Precise release
期刊名称：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS （ 影响因子：7.328； 五年影响因子：6.654 ）
ISSN： 0928-4931
年卷期： 2019 年 96 卷
页码：
收录情况： SCI
摘要： Cyclodextrins, one of safe excipients, are able to form host-guest complexes with fitted molecules given the unique nature imparted by their structure in result of a number of pharmaceutical applications. On the other hand, targeted or responsive materials are appealing therapeutic platforms for the development of next-generation precision medications. Meanwhile, cyclodextrin-based polymers or assemblies can condense DNA and RNA in result to be used as genetic therapeutic agents. Armed with a better understanding of various pharmaceutical mechanisms, especially for cancer treatment, researchers have made lots of works about cyclodextrin-based drug delivery systems in materials chemistry and pharmaceutical science. This Review highlights recent advances in cyclodextrin-based delivery systems for cancer treatment capable of targeting or responding to the physiological environment. Key design principles, challenges and future directions, including clinical translation, of cyclodextrin-based delivery systems are also discussed.
- 相关文献
作者其他论文 更多>>
-
Comprehensive high-throughput sequencing, evolutionary and functional analyses reveal the conservation and diversification of miR166s in regulating pleiotropic traits between rapeseed and Arabidopsis
作者：Zhang, Liyuan;Chen, Si;Yang, Ziyan;Xu, Jinxiong;Sun, Tingting;Kong, Xizeng;Qu, Cunmin;Li, Jiana;Zhang, Liyuan;Lu, Kun;Zhang, Chao;Yang, Bo;Kang, Lin
关键词：High -throughput sequencing; Pleiotropic traits; MiR166/HD-Zip III; Functional research; Rapeseed and Arabidopsis
-
Integrating GWAS, RNA-Seq and functional analysis revealed that BnaA02.SE mediates silique elongation by affecting cell proliferation and expansion in Brassica napus
作者：Zhang, Liyuan;Li, Xiaodong;Chen, Si;Xiang, Sirou;Sun, Tingting;Yang, Ziyan;Kong, Xizeng;Qu, Cunmin;Li, Jiana;Yang, Bo;Zhang, Chao;Lu, Kun
关键词：Brassica napus; silique elongation; GWAS; transcriptome analysis; BnaA02.SE; functional research
-
Cyclodextrin-based multifunctional supramolecular catalysts for aqueous CuAAC reaction
作者：Li, Jianbo;Feng, Xuepu;Wang, Wenting;Yang, Jing;Li, Xiang;Yang, Rui;Yang, Bo;Guo, Mengbi
关键词：Bioorthogonal chemistry; Click reaction; CuAAC; Supramolecular catalysis; Polycyclodextrin; Triazole
-
Whole-genome resequencing of wild and cultivated cannabis reveals the genetic structure and adaptive selection of important traits
作者：Chen, Xuan;Guo, Hong-Yan;Zhang, Qing-Ying;Guo, Rong;Lv, Pin;Xu, Yan-Ping;Guo, Meng-Bi;Zhang, Yuan;Zhang, Kun;Yang, Ming;Wang, Lu;Zhan, Yi-Xun;Liu, Yan-Hu
关键词：Cannabis; Wild; Cultivated; Whole-genome resequencing; Genetic structure; Flowering
-
Preparation of poly(e-lysine)-cyclodextrin coated Fe3O4 nanoparticles for selective separation of natural medicine: Scutellarin
作者：Liao, Rongqiang;Jiang, Dexi;Liu, Ying;Lv, Pin;Lv, Pin
关键词：Cyclodextrin; Nanoparticles; Separation; Scutellarin
-
Acyclic cucurbit[n]urils-based supramolecular encapsulation for enhancing the protective effect of capsaicin on gastric mucosa and reducing irritation
作者：Zhou, Jiawei;Lv, Pin;Zhang, Shuqing;Zhang, Yazhou;Yang, Jing;Yang, Bo;Zhang, Ruihao;Lv, Pin
关键词：Acyclic cucurbit[n]urils; Capsaicin; Inclusion complex; Bioavailability; Gastric mucosal injury; Toxicity
-
Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol
作者：Zhu, Panyong;Lv, Pin;Zhang, Yazhou;Liao, Xiali;Gao, Chuanzhu;Yang, Bo;Lv, Pin;Guo, Rong;Chen, Xuan;Yang, Ming;Liao, Rongqiang;Liu, Jing;Zhang, Kun
关键词：biotin; ss-cyclodextrin; cannabidiol; inclusion complex; targeting delivery; self-assembly
