Structural analysis and cytotoxicity of host-guest inclusion complexes of cannabidiol with three native cyclodextrins
文献类型： 外文期刊
作者： Lv, Pin 1 ; Zhang, Dongjing 2 ; Guo, Mengbi 1 ; Liu, Jing 3 ; Chen, Xuan 1 ; Guo, Rong 1 ; Xu, Yanping 1 ; Zhang, Qingyin 1 ;
作者机构： 1.Yunnan Acad Agr Sci, Ind Crop Res Inst, Kunming 650205, Yunnan, Peoples R China
2.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China
3.Anhui Med Univ, Coll Basic Med, Dept Pharmacol, Hefei 230023, Anhui, Peoples R China
4.Chongqing Univ, Affiliated Cent Hosp, Chongqing Emergency Med Ctr, Dept Pharm, Chongqing 400014, Peoples R China
关键词： Cannabidiol; Cyclodextrins; Inclusion complex; Solubilization; Cytotoxicity
期刊名称：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY （ 影响因子：3.981； 五年影响因子：3.833 ）
ISSN： 1773-2247
年卷期： 2019 年 51 卷
页码：
收录情况： SCI
摘要： The preparation of inclusion complex is often used to improve the physicochemical properties of poorly soluble drugs. In this work, we successfully prepared inclusion complexes of cannabidiol (CBD) with three native cyclodextrins by suspension method, respectively named alpha-cyclodextrins (alpha-CD), beta-cyclodextrins (beta-CD), and gamma-cyclodextrins (gamma-CD). Many methods including H-1 and 2D NMR analysis, X-ray power diffraction (XRD), scanning electron microscopy (SEM) analysis and thermal gravimetric analysis (TGA) were used to characterize the inclusion behaviors of the inclusion complexes of cannabidiol with cyclodextrins both in solution and solid forms. The results indicated that cannabidiol were encapsulated within the cavity of alpha-CD, beta-CD and gamma-CD to form a 1:1, 2:1 and 2:1 host-guest inclusion complex, and possible inclusion modes of cannabidiol with three CDs were speculated. The water solubility and in vitro cytotoxicity of the inclusion complexes were respectively evaluated by the methods of saturated solution and MTT additionally. It is noteworthy that significant increases in the water solubility and in vitro cytotoxicity of cannabidiol were found in the form of inclusion complex with three natural cyclodextrins compared with free cannabidiol.
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