文献类型： 外文期刊
作者： Zhu, Panyong 1 ; Lv, Pin 1 ; Zhang, Yazhou 1 ; Liao, Rongqiang 3 ; Liu, Jing 4 ; Guo, Rong 2 ; Chen, Xuan 2 ; Liao, Xiali 1 ;
作者机构： 1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China
2.Yunnan Acad Agr Sci, Ind Crop Res Inst, Kunming, Yunnan, Peoples R China
3.Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Pharm Dept, Chongqing, Peoples R China
4.Kunming Med Univ, Affiliated Stomatol, Kunming, Yunnan, Peoples R China
5.Yunnan Univ, Sch Agr, Kunming, Yunnan, Peoples R China
关键词： biotin; ss-cyclodextrin; cannabidiol; inclusion complex; targeting delivery; self-assembly
期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.221； 五年影响因子：5.385 ）
ISSN： 2296-2646
年卷期： 2021 年 9 卷
页码：
收录情况： SCI
摘要： Cannabidiol (CBD) is one specific kind of the cannabinoid in Cannabis sativa L with a wide range of pharmacological activities. However, the poor water solubility and specificity of CBD limits its application in pharmaceutical field. For solving these problems, in this work, we successfully prepared a targeted carrier by grafting biotin (BIO) onto ethylenediamine-beta-Cyclodextrin (EN-CD) in a single step to generate a functionalized supramolecule, named BIO-CD. Subsequently, an amantadine-conjugated cannabinoids (AD-CBD) was prepared and self-assembled with the BIO-CD. A series of methods were used to characterize the inclusion behavior and physicochemical properties of AD-CBD and BIO-CD. The results showed that AD-CBD entered the cavity of BIO-CD and formed a 1:1 host-guest inclusion complex. MTT assay and confocal laser scanning microscopy (CLSM) revealed that the targeting effect and anticancer activity of AD-CBD/BIO-CD inclusion complex against three human cancer cell lines were higher than BIO-CD, AD-CBD and free CBD. Moreover, the inclusion complex could release drugs under weakly acidic conditions. These results demonstrated that AD-CBD/BIO-CD inclusion complex possess excellent targeted and anticancer activity, which is hopeful to be applied in clinic as a new therapeutic approach.
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