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Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases

文献类型： 外文期刊

作者： Zeng, Yawen 1 ; Pu, Xiaoying 1 ; Du, Juan 1 ; Yang, Xiaomeng 1 ; Li, Xia 1 ; Mandal, Md. Siddikun Nabi 2 ; Yang, Tao 1 ;

作者机构： 1.Yunnan Acad Agr Sci, Biotechnol & Germplasm Resources Inst, Agr Biotechnol Key Lab Yunnan Prov, Kunming 650205, Yunnan, Peoples R China

2.Bangladesh Wheat & Maize Res Inst, Nashipur 5200, Dinajpur, Bangladesh

3.Minist Agr, Key Lab Southwestern Crop Gene Resources & Germpl, Kunming 650205, Yunnan, Peoples R China

期刊名称：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY （ 影响因子：6.543； 五年影响因子：7.454 ）

ISSN： 1942-0900

年卷期： 2020 年 2020 卷

页码：

收录情况： SCI

摘要： Barley plays an important role in health and civilization of human migration from Africa to Asia, later to Eurasia. We demonstrated the systematic mechanism of functional ingredients in barley to combat chronic diseases, based on PubMed, CNKI, and ISI Web of Science databases from 2004 to 2020. Barley and its extracts are rich in 30 ingredients to combat more than 20 chronic diseases, which include the 14 similar and 9 different chronic diseases between grains and grass, due to the major molecular mechanism of six functional ingredients of barley grass (GABA, flavonoids, SOD, K-Ca, vitamins, and tryptophan) and grains (beta-glucans, polyphenols, arabinoxylan, phytosterols, tocols, and resistant starch). The antioxidant activity of barley grass and grain has the same and different functional components. These results support findings that barley grain and its grass are the best functional food, promoting ancient Babylonian and Egyptian civilizations, and further show the depending functional ingredients for diet from Pliocene hominids in Africa and Neanderthals in Europe to modern humans in the world. This review paper not only reveals the formation and action mechanism of barley diet overcoming human chronic diseases, but also provides scientific basis for the development of health products and drugs for the prevention and treatment of human chronic diseases.

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