Separation of enantiomers by high performance liquid chromatography using derivants of L-proline as chiral mobile phase additives
文献类型： 外文期刊
作者： Chang Yinxia 1 ; Hou Zhilin 2 ; Li Qiwan 2 ; Gao Tianrong 2 ; Yuan Liming 2 ;
作者机构： 1.Yunnan Normal Univ, Sch Chem & Chem Sci, Kunming 650092, Peoples R China
2.Yunnan Normal Univ, Sch Chem & Chem Sci, Kunming 650092, Peoples R China; Shanxi Teachers Univ, Sch Chem & Mat Sci, Linfen 041000, Peoples R China; Yunnan Acad Agr Sci, Inst Qual Stand & Testing Technol, Kunming 650223, Peoples R China
关键词： N-dodecanoyl-L-proline;N-dodecanoyl-L-proline-3,5-dimethylanilide;high performance liquid chromatography;mobile phase addition
期刊名称：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.134； 五年影响因子：0.909 ）
ISSN： 0253-3820
年卷期： 2006 年 34 卷
页码：
收录情况： SCI
摘要： N-dodecanoyl-L-proline and N-dodecanoyl-L-proline-3, 5-dimethylanilide derived from L-proline were used as chiral mobile phase additives. Enantiomers were separated using hexane and isopropanol as mobile phase on a aminopropyl silica gel column by high performance liquid chromatography. The results show that the enantioselectivity of N-dodecanoyl-L-proline is better and eight enantiomers of the twelve enantiomers can be separated. The enantioselectivity of N-dodecanoyl-L-proline-3,5-dimethyl-anilide is also good, but the basic line fluctuates strongly due to containing benzene ring in its molecular structure.
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