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Benzylphenethylamine Alkaloids from Hosta plantaginea with Inhibitory Activity against Tobacco Mosaic Virus and Acetylcholinesterase

文献类型： 外文期刊

作者： Wang, Yue-Hu 1 ; Zhang, Zhong-Kai 2 ; Yang, Fu-Mei 2 ; Sun, Qian-Yun 3 ; He, Hong-Ping; Di, Ying-Tong; Mu, Shu-Z 1 ;

作者机构： 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China; Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; Yunnan Acad Agr Sci, Yunnan Key Lab Agr Biotechnol, Kunming 650223, Peoples R China; Chinese Acad Sci, Guiyang 550002, Peoples R China; Key Lab Chem Nat Prod Guizhou Prov, Guiyang, Peoples R China; Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

3.Chines

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

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收录情况： SCI

摘要： Five new benzylphenethylamine alkaloids,hostasine(1),8-demethoxyhostasine,8-demethoxy-10-O-methylhostasine,10-O-methylhostasine,and 9-O-demethyl-7-O-methyllycorenine,along with 12 known compounds,were isolated from Hosta plantaginea by bioassay-guided fractionation.The structures of the new alkaloids were established by means of extensive spectroscopic methods,and the relative configuration of 1 was further confirmed by single-crystal X-ray diffraction.7-Deoxy-trans-dihydronarciclasine(IC_(50)= 1.80 mu M),a known alkaloid,showed strong activity against tobacco mosaic virus by the half-leaf method.Some of these alkaloids were also evaluated for their inhibitory activity against acetylcholinesterase.8-Demethoxy-10-O-methylhostasine was found to possess significant activity,with an IC_(50)of 2.32 mu M.

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