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Quinolizidine Alkaloids and Isoflavones from the Herb of Thermopsis lupinoides and Their Antiviral, Antifungal, and Insecticidal Activities

文献类型： 外文期刊

作者： Zhang, Tong 1 ; Tian, Cai-Yan 1 ; Zhang, Ji 1 ; An, Qiao 1 ; Yi, Ping 1 ; Yuan, Chun-Mao 1 ; Zhang, Zhong-Kai 5 ; Zhao, Li-Hua 5 ; Hao, Xiao-Jiang 1 ; Hu, Zhan-Xing 1 ;

作者机构： 1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China

2.Nat Prod Res Ctr Guizhou Prov, Guiyang 550014, Peoples R China

3.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Peoples R China

4.Guizhou Univ Tradit Chinese Med, Sch Pharm, Guiyang 550025, Peoples R China

5.Yunnan Acad Agr Sci, Inst Biotechnol & Germplasm Resources, Kunming 650204, Peoples R China

6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650201, Peoples R China

关键词： Thermopsis lupinoides; quinolizidinealkaloids; isoflavones; anti-TSWV; antifungalactivity; insecticidal activity

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 9 期

页码：

收录情况： SCI

摘要： As part of our ongoing investigation of natural bioactive substances from the genus Thermopsis of the tribe Fabaceae for agricultural protection, the chemical constituents of the herb Thermopsis lupinoides were systematically investigated, which led to the isolation of 39 quinolizidine alkaloids (QAs) (1-39), including 14 new QAs (1-14) and 14 isoflavones (40-53). Their structures were elucidated through comprehensive spectroscopic data analysis (IR, UV, NMR, HRESIMS), ECD calculations, and X-ray crystallography. The antitomato spotted wilt virus (TSWV) and antifungal (against Botrytis cinerea, Gibberella zeae, Phytophythora capsica, and Alternaria alternata) and insecticidal (against Aphis fabae and Tetranychus urticae) activities of the isolated compounds were screened using the lesion counting method, mycelial inhibition assay, and spray method, respectively. The bioassay results showed that 34 exhibited excellent protective activity against TSWV, with an EC50 value of 36.04 mu g/mL, which was better than that of the positive control, ningnanmycin (86.03 mu g/mL). The preliminary mechanistic exploration illustrated that 34 induced systemic acquired resistance in the host plant by acting on the salicylic acid signaling pathway. Moreover, 1 showed significant antifungal activity against B. cinerea (EC50 value of 20.83 mu g/mL), while 2 exhibited good insecticidal activity against A. fabae (LC50 value of 24.97 mu g/mL). This research is promising for the invention of novel pesticides from QAs with high efficiency and satisfactory ecological compatibility.

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