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Quinolizidine Alkaloids with Antiviral and Insecticidal Activities from the Seeds of Sophora tonkinensis Gagnep

文献类型： 外文期刊

作者： Zou, Jibin 1 ; Zhao, Lihua 5 ; Yi, Ping 1 ; An, Qiao 1 ; He, Longxiang 4 ; Li, Yanan 1 ; Lou, Huayong 1 ; Yuan, Chunmao 1 ;

作者机构： 1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China

2.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China

3.Chinese Acad Sci, Guiyang 550002, Peoples R China

4.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Peoples R China

5.Yunnan Acad Agr Sci, Inst Biotechnol & Germplasm Resources, Kunming 650204, Yunnan, Peoples R China

关键词： Sophora tonkinensis Gagnep.; matrine-type alkaloids; cytisine-type alkaloids; anti-TMV; insecticidal activity; structure-activity relationship

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2020 年 68 卷 50 期

页码：

收录情况： SCI

摘要： The discovery of novel, effective, and botanical pesticides is one of the main strategies for modern plant protection and insect pest control. During the search for novel botanical pesticides from natural sources, the seeds of Sophora tonkinensis were systematically investigated to obtain 11 new matrine-type alkaloids (1-11), including one novel matrine-type alkaloid featuring an unprecedented 5/6/6/6 tetracyclic skeleton (1), along with 16 known compounds (12-27). Their structures were elucidated by comprehensive spectroscopic data analysis (IR, UV, NMR, and HRESIMS), ECD calculations, and single-crystal X-ray diffraction. The anti-tobacco mosaic virus (TMV) activity and insecticidal activities against Aphis fabae and Tetranychus urticae of the compounds were also respectively screened using the half-leaf method and spray method. Biological tests indicated that compounds 2, 4, 6, and 26 displayed significant anti-TMV biological activities compared with the positive control ningnanmycin. Compounds 7, 17, and 26 presented moderate activities against A. fabae with LC50 values of 38.29, 18.63, and 23.74 mg/L, respectively. Moreover, compounds 13 and 26 exhibited weak activities against T. urticae.

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