文献类型： 外文期刊
作者： He, Yi-Lin 1 ; Zhang, Lan-Jun 2 ; Li, Guo-Li 1 ; Yang, Hong-Ying 1 ; Zhang, Lei 1 ; Gong, Zheng 1 ; Gao, Kun 2 ;
作者机构： 1.Lanzhou Jiaotong Univ, Res Inst, Sch Chem & Chem Engn, Lanzhou 730070, Peoples R China
2.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
3.Yunnan Acad Agr Sci, Tea Res Inst, Kunming 650201, Peoples R China
关键词： Jatropha curcas L.; Euphorbiaceae; Jatrophane diterpenoids; Multidrug resistance reversal activities
期刊名称：FITOTERAPIA （ 影响因子：2.6； 五年影响因子：3.0 ）
ISSN： 0367-326X
年卷期： 2025 年 180 卷
页码：
收录情况： SCI
摘要： Nine jatrophane diterpenoids, including six previously undescribed compounds, were extracted and purified from whole plants of Jatropha curcas L. Their structures including absolute configurations were characterized by spectroscopic, quantum chemical Nuclear Magnetic Resonance Spectroscopy, Electronic Circular Dichroism calculation, and Single Crystal X-Ray Diffraction methods. These compounds were evaluated for their ability to reverse multidrug resistance. Among the above compounds, compound 6 showed significant potential as a multidrug resistance modulator, exhibiting higher chemo reversal effects and lower toxicity compared to the positive control verapamil. These findings suggest that compound 6 has promising anticancer properties.
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