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13-Cyclodextrin as a booster for ultrasound-assisted extraction of secoiridoids from Gentiana rigescens using a biobased deep eutectic solvent

文献类型： 外文期刊

作者： Yang, Yang 1 ; Zhao, Ru 2 ; Gao, Hongfei 1 ; Wang, Zehao 1 ; Ruan, Ming 2 ; Gu, Huiyan 3 ; Yang, Lei 1 ; Tian, Hao 5 ; Fan, Changwen 1 ; Liu, Tingting 6 ;

作者机构： 1.Northeast Forestry Univ, Coll Chem Chem Engn & Resource Utilizat, Harbin 150040, Peoples R China

2.Nanjing Xiaozhuang Univ, Key Lab Qual & Safety Agr Prod Nanjing, Nanjing 211171, Peoples R China

3.Northeast Forestry Univ, Sch Forestry, Harbin 150040, Peoples R China

4.Northeast Forestry Univ, Minist Educ, Key Lab Forest Plant Ecol, Harbin 150040, Peoples R China

5.Yunnan Acad Agr Sci, Agroprod Proc Res Inst, Kunming 650223, Peoples R China

6.Qiqihar Med Univ, Coll Pharm, Qiqihar 161006, Peoples R China

关键词： Cyclodextrin; Biobased deep eutectic solvent; Gentiana rigescens Franch. ex Hemsl; Secoiridoid; Ultrasound-assisted extraction

期刊名称：INDUSTRIAL CROPS AND PRODUCTS （ 影响因子：5.9； 五年影响因子：6.0 ）

ISSN： 0926-6690

年卷期： 2023 年 204 卷

页码：

收录情况： SCI

摘要： In this study, secoiridoids (gentiopicroside, loganic acid, swertiamaroside, and sweroside) were extracted from Gentiana rigescens roots and rhizomes with 13-cyclodextrin (13-CD) as the booster and biobased glycine-glycerol deep eutectic solvent (DES) as the extraction solvent and with ultrasound-assisted extraction. The molecular docking performances showed that in DES aqueous solution, 13-CD interacts with secoiridoids through non covalent bonds and hydrogen bonds, and the four secoiridoids studied can be well adapted to the hydrophobic cavity of 13-CD. The hydrogen bonds present between secoiridoids and 13-CD all reached more than four, and the corresponding binding energies were all lower than 5.0 kcal/mol. The yields of gentiopicroside, loganic acid, swertiamaroside, and sweroside were 39.82 & PLUSMN; 2.05 mg/g, 6.61 & PLUSMN; 0.34 mg/g, 0.79 & PLUSMN; 0.04 mg/g, and 0.57 & PLUSMN; 0.04 mg/g, respectively, under optimal extraction conditions. The results showed that ultrasound-assisted extraction of secoiridoid compounds in G. rigescens with an aqueous 13-CD/DES solution was more effective compared with conventional extraction solvents, which provides a scientific basis for the promising use of 13-CD/ DES as extraction solvents in natural drugs.

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