文献类型： 外文期刊
作者： Tang, Wenru 1 ; Zhou, Xuhong 3 ; Nie, Shengjie 4 ; Yang, Zhi 4 ; Zhu, Hui 2 ; Wu, Xiaoming 2 ; Zhao, Ruoping 1 ; Luo, Yin 1 ;
作者机构： 1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
2.Kunming Univ Sci & Technol, Fac Med, Lab Mol Genet Aging & Tumor, Kunming 650500, Yunnan, Peoples R China
3.Yunnan Acad Agr Sci, Flower Res Inst, Kunming, Peoples R China
4.Kunming Med Univ, Kunming, Peoples R China
关键词： p53;meta-analysis;gastric cancer
期刊名称：BIOMARKERS （ 2020影响因子：2.658； 五年影响因子：2.347 ）
收录情况： SCI
摘要： Background: p53 tumor suppressor gene Arg72Pro polymorphism has been associated with gastric cancer. However, results were inconsistent. We performed this meta-analysis to estimate the association between p53 Arg72Pro polymorphism and gastric cancer. Methods: An electronic search of PubMed was conducted to select studies. Studies containing available genotype frequencies of Arg72Pro were chosen, and the association was assess by pooled odds ratio (ORs) with 95% confidence interval (CIs). Results: The meta-analysis suggested that the p53 Arg72Pro was associated with the gastric cancer risk (Additive model: OR = 1.149, 95% Cl = 1.045-1.263, p = 0.004; Dominant model: OR = 1.18, 95% Cl = 1.049-1.328, p = 0.006; Recessive model: OR = 1.202,95% Cl = 1.013-1.427, p = 0.035) in Asian subgroup. Conclusion:This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of gastric cancer in Asians.
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