Simultaneous determination of six index constituents and comparative analysis of four ethnomedicines from genus Gentiana using a UPLC-UV-MS method
文献类型： 外文期刊
作者： Pan, Yu 1 ; Shen, Tao 3 ; Zhang, Ji 1 ; Zhao, Yan-Li 1 ; Wang, Yuan-Zhong 1 ; Li, Wan-Yi 1 ;
作者机构： 1.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650200, Peoples R China
2.Yunnan Univ Tradit Chinese Med, Coll Tradit Chinese Med, Kunming 650500, Peoples R China
3.Yuxi Normal Univ, Coll Resources & Environm, Yuxi 653100, Peoples R China
关键词： UPLC-UV-MS;MS;ethnomedicines;Gentiana;fingerprints;principal component analysis
期刊名称：BIOMEDICAL CHROMATOGRAPHY （ 影响因子：1.902； 五年影响因子：1.809 ）
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收录情况： SCI
摘要： Many species from genus Gentiana (Gentianaceae) have a long history of applications as folk medicines in the world. A simple rapid UPLC-UV-MS/MS method has been developed and validated for the simultaneous determination of six index constituents (gentiopicroside, swertiamarin, loganic acid, sweroside, mangiferin and ferulic acid) from the four ethnomedicines (G. rigescens Franch. ex Hemsl., G. rhodantha Franch. ex Hemsl., G. scabra Bunge and G. farreri Balf. f.). The UPLC analysis was performed on Shim-Pack XR-ODS III (150x2.0mm, 2.2 mu m). The mobile phase was consisted of acetonitrile-0.1% formic acid water using gradient elution. The wavelength 242nm was chose for the four iridoids as well as mangiferin and 320nm was set for ferulic acid. Mass spectrometry was applied for identification and quantification for analytes with low concentration. All the regression equations revealed a good linear relationship (R-2>0.9993). Accuracy and precision were all within the required limits. The chromatogram fingerprints analysis combined with principal component analysis showed the similarity values of the four species were <0.788 while the similarity values of G. scabra Bunge and G. rigescens Franch. ex Hemsl. were >0.993, which provided reasonable foundation for utilization and clinical application of the four ethnomedicines. This developed method appears to be a useful tool for quality control of the four ethnomedicines. Copyright (c) 2014 John Wiley & Sons, Ltd.
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