Anti-Inflammatory Dimeric and Trimeric Flavonoids from the Roots ofPistacia weinmannifolia
文献类型： 外文期刊
作者： Lee, Seong Mi 1 ; Ryu, Hyung Won 1 ; Kim, Hyoung-Geun 1 ; Jo, Yang Hee 1 ; Park, Kyoung Jin 5 ; Lee, Su Ui 1 ; Oh, Eun Sol 1 ; Lee, Sang Woo 6 ; Choi, Sangho 6 ; Li, Wan-Yi 7 ; Hwang, Bang Yeon 3 ; Oh, Sei-Ryang 1 ;
作者机构： 1.Korea Res Inst Biosci & Biotechnol, Nat Prod Res Ctr, Cheongju 28116, Chungcheungbuk, South Korea
2.Korea Res Inst Biosci & Biotechnol, Nat Prod Cent Bank, Cheongju 28116, Chungcheungbuk, South Korea
3.Chungbuk Natl Univ, Coll Pharm, Cheongju 28644, South Korea
4.Natl Inst Food & Drug Safety Evaluat, Minist Food & Drug Safety, Herbal Med Res Div, Chungju 28159, Chungcheongbuk, South Korea
5.Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea
6.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, South Korea
7.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650200, Peoples R China
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.6； 五年影响因子：4.2 ）
ISSN： 0163-3864
年卷期： 2025 年 88 卷 2 期
页码：
收录情况： SCI
摘要： As part of an ongoing search for new anti-inflammatory agents from medicinal plants, five new dimeric and trimeric flavonoids (1-5) were isolated from the roots of Pistacia weinmannifolia. The structures of pistachalcone A (1), pistachalcone B (2), pistaflavanone A (3), pistachalcone C (4), and pistachalcone D (5) were elucidated by the analysis of spectroscopic data. The known compounds rhuschalcone II (6), rhuschalcone VI (7), and pauferrol B (8) were also isolated and identified. Our in vitro analysis found that compounds isolated from P. weinmannifolia root extract exert anti-inflammatory effects in phorbol myristate acetate (PMA)-induced NCI-H292 airway epithelial cells by the suppression of expression levels such as interleukin-8 (IL-8) and mucin 5AC (MUC5AC), which are closely related to the pulmonary inflammatory response in the pathogenesis of COPD. Therefore, these dihydrochalcone derivatives may have value as new starting materials for the development of drug candidates against COPD.
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