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Design, Synthesis, and Biological Activities of Aromatic Gossypol Schiff Base Derivatives

文献类型: 外文期刊

作者: Li, Ling 1 ; Li, Zheng 1 ; Wang, Kailiang 1 ; Zhao, Sheng; Feng, Jiming; Li, Jiarui; Yang, Peiwen; Liu, Yuxiu 1 ;

作者机构: 1.Nankai Univ, State Key Lab Elementoorgan Chem, Res Inst Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

2.Nankai Univ, State Key Lab Elementoorgan Chem, Res Inst Elementoorgan Chem, Collab

关键词: gossypol;Schiff base;synthesis;anti-TMV activity;structure-activity relationships

期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )

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年卷期:

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收录情况: SCI

摘要: A series of aromatic gossypol Schiff bases have been successfully synthesized via a feasible chemical modification. The antiviral activity against tobacco mosaic virus (TMV) of these gossypol Schiff bases has been tested for the first time. The bioassay studies indicated most of these derivatives exhibited excellent anti-TMV activity, in which o-trifluoromethylaniline Schiff base (19) displayed the best antiviral activities. Furthermore, compound 19 exhibited an eminent anti-TMV effect in the field and low toxicity to mice. These results suggest it is a promising candidate for the inhibitor of plant virus.

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