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Anti-inflammatory effects of a methanolic extract of Castanea seguinii Dode in LPS-induced RAW264.7 macrophage cells

文献类型： 外文期刊

作者： Lim, Yourim 1 ; Park, Ji-Won 1 ; Kwon, Ok-Kyoung 1 ; Lee, Jae-Won 1 ; Lee, Han-Sol 1 ; Lee, Sangwoo 3 ; Choi, Sangho;

作者机构： 1.Korea Res Inst Biosci & Biotechnol, Nat Med Res Ctr, 30 Yeongudanji Ro, Cheonju Si 28116, Chungcheongbuk, South Korea

2.Chungbuk Natl Univ, Coll Pharm, Osongsaengmyeong 1 Ro, Cheonju Si 28160, Chungcheongbuk, South Korea

3.Kore

关键词： Castanea seguinii;anti-inflammatory;RAW264;7;lipopolysaccharide;nuclear factor-B;mitogen-activated protein kinase

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE （ 影响因子：4.101； 五年影响因子：4.084 ）

ISSN： 1107-3756

年卷期： 2018 年 41 卷 1 期

页码：

收录情况： SCI

摘要： Castanea extracts are known to have antioxidant properties and are used as a traditional medicine in China and Asia. However, the biological activity of Castanea seguinii Dode has remained to be fully elucidated. The present study investigated the anti-inflammatory effects of a Castanea seguinii Dode methanolic extract (CSME) on lipopolysaccharide-induced RAW264.7 macrophage cells. CSME inhibited the production of nitric oxide (NO) and the expression of inducible NO synthase. It also suppressed the production of the pro-inflammatory cytokines inteleukin-6 and tumor necrosis factor-, as well as chemokine monocyte chemoattractant protein 1. In addition, CSME inhibited nuclear factor-B (NF-B) and mitogen-activated protein kinase (MAPK) signaling, while also downregulating transcription factor activator protein-1. Furthermore, CSME increased heme oxygenase 1 through the upregulation of NF (erythroid-derived 2)-like-2 (Nrf-2), which directly or indirectly affects inflammation. It also increased the phosphorylation of 5-adenosine monophosphate-activated protein kinase (AMPK). In conclusion, CSME was demonstrated to exert its anti-inflammatory activities through the inhibition of the NF-B and the MAPK signaling pathways, as well as the activation of Nrf-2 and AMPK. These results indicated that CSME may be a promising for development as a commercial anti-inflammatory medicine.

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