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Characterization of an inhibitor of apoptosis gene (BmSurvivin-2) from the silkworm, Bombyx mori

文献类型： 外文期刊

作者： Tang, Xu-Dong 1 ; Tu, Qiang 2 ; Mao, Fei 3 ; Bai, Xing-Rong 5 ; Zhu, Feng 5 ;

作者机构： 1.Jiangsu Univ Sci & Technol, Zhenjiang 212018, Jiangsu, Peoples R China

2.Jiangning Hosp Nanjing, Nanjing 211100, Jiangsu, Peoples R China

3.Jiangsu Univ, Sch Med, Affiliated Hosp, Key Lab Med Sci, Zhenjiang 212013, Jiangsu, Peoples R China

4.Jiangsu Univ, Sch Med, Affiliated Hosp, Lab Med Jiangsu Prov, Zhenjiang 212013, Jiangsu, Peoples R China

5.Yunnan Acad Agr Sci, Inst Sericulture & Apiculture, Mengzi 661101, Yunnan, Peoples R China

关键词： Inhibitor of apoptosis protein;BIR domain;Silkworm;Wandering

期刊名称：JOURNAL OF ASIA-PACIFIC ENTOMOLOGY （ 影响因子：1.303； 五年影响因子：1.427 ）

ISSN： 1226-8615

年卷期： 2017 年 20 卷 4 期

页码：

收录情况： SCI

摘要： The inhibitor of apoptosis proteins (IAP) plays an important role in maintaining the balance between cell proliferation and cell death. Here, we describe an IAP named BmSurvivin-2 isolated from tissues of Bombyx mod that contains only one baculoviral IAP repeat (BIR) domain and lacks a really interesting new gene (RING) finger domain. Cell viability and DNA fragment analysis showed that over-expression of BmSurvivin-2 could inhibit actinomycin D (ActD)-induced apoptosis in Sf9 cells, and its anti-apoptotic activity was dependent on its N terminal BIR domain. Real-time PCR analyses indicated that BmSurvivin-2 mRNA was expressed in all tissues of silkworm and the highest expression level was found in testis and head. Expression of BmSurvivin-2 was found to gradually increase during the wandering stage of silkworm and decreased after wandering. Similar to deterin but not survivin, BmSurvivin-2 was primarily located in the cytoplasm. All these results provide insight into the role of a novel IAP in the silkworm, B. mori.

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