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Phytochemistry and Pharmacological Activities of the Genus Swertia (Gentianaceae): A Review

文献类型： 外文期刊

作者： Li, Jie 1 ; Zhao, Yan-Li 1 ; Huang, Heng-Yu 2 ; Wang, Yuan-Zhong 1 ;

作者机构： 1.Yunnan Acad Agr Sci, Inst Med Plants, 2238 Beijing Rd, Kunming 650200, Peoples R China

2.Yunnan Univ Tradit Chinese Med, Coll Tradit Chinese Med, 1076 Yuhua Rd, Kunming 650500, Peoples R China

关键词： Swertia Genus;Phytochemistry;Pharmacological Activities;Biosynthetic Pathway;Review

期刊名称：AMERICAN JOURNAL OF CHINESE MEDICINE （ 影响因子：4.667； 五年影响因子：4.135 ）

ISSN： 0192-415X

年卷期： 2017 年 45 卷 4 期

页码：

收录情况： SCI

摘要： Swertia plants have been considered to be medicinal plants useful for the treatment of various ailments for thousands of years, especially in Asian countries. This is due to the broad variety of chemical compounds that provide multiple ligands for bonding to different endogenous biomacromolecules for patients. Chemical constituents and pharmacological activities of Swertia plants are summarized in this paper. Approximately 419 metabolites and 40 bioactive compounds have been reported from 30 Swertia species, including xanthones, flavonoids, seco-iridiods, iridiods, triterpenoids, alkaloids, volatiles, and other secondary metabolites. The bioactivities of Swertia plants include anticarcinogenic, hepatoprotective, anti-oxidant, hypoglycemic, anthelmintic, antibacterial, antifungal, anti-diabetic, gut, and airways modulatory, metabolizing isozymes inhibitory, neuroprotective, HIV-I reverse transcriptases inhibitory, anticholinergic, and CNS-depressant activities, etc. In addition, biosynthetic pathways of xanthones, and seco-iridiods, two most important secondary metabolites for Swertia, are elucidated. The xanthones biosynthetic pathway is a mixed biosynthetic pathway involved the shikimate and the malonate routes, and the seco-iridoid pathway starts with geraniol derived from IPP which is produced either via the MEP or the MVA pathway. This review will offer a reference for future researches on the protection of natural resources, the investigation of therapeutic basis, new drug development, and so forth. Metabolic pathways of some crucial active compounds were also discussed in this review.

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