文献类型： 外文期刊
作者： Li, Bin 1 ; Chen, Daomei 1 ; Li, Wanyi 2 ; Xiao, Dan 2 ;
作者机构： 1.Yunnan Univ, Minist Educ, Sch Pharm, Key Lab Med Chem Nat Resources,Sch Chem Sci & Tec, 2 Chuihu Rd, Kunming 650091, Yunnan, Peoples R China
2.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650223, Yunnan, Peoples R China
关键词： Panax notoginseng saponins;migration;ostopontin;ovarian cancer;SKOV3 cells;tube formation
期刊名称：ONCOLOGY LETTERS （ 影响因子：2.967； 五年影响因子：2.575 ）
ISSN： 1792-1074
年卷期： 2016 年 11 卷 3 期
页码：
收录情况： SCI
摘要： While the anti-tumor actions of ginsenosides from Panax notoginseng are well-studied, the anti-proliferative activity of 20(S)-protopanaxadiol saponins (PDS) in Sanchi ginseng on human ovarian cancer has not been reported, nor has its effect on migration of SKOV3 cells been investigated. In the present study, a wound-healing assay indicated that PDS inhibited the migration of SKOV3 cells, and a Matrigel tube formation assay demonstrated the presence of inhibitory tube-structures following treatment with PDS. To date, there are no previous reports on the regulation of osteopontin (OPN), a glycophosphoprotein cytokine frequently expressed in ovarian carcinoma effusions by PDS. A reduction in the expression of OPN following PDS-treatment was observed using immunohistochemical and western blot experiments. These results suggest that PDS may be useful in the search for a potential ovarian cancer treatment.
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