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Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr.

文献类型： 外文期刊

作者： Yan, Xiao-Hui 1 ; Chen, Jia 1 ; Di, Ying-Tong 1 ; Fang, Xin 1 ; Dong, Jia-Hong 3 ; Sang, Peng; Wang, Yue-Hu 1 ; He, Ho 1 ;

作者机构： 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

3.Yunnan Acad Agr Sci, Kunming 650023, Yunnan, Peoples R China

关键词： Tobacco mosaic virus (TMV);Brucea javanica (L.) Merr.;quassinoids;structure-activity relationship (SAR).

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

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收录情况： SCI

摘要： Two new quassinoids, javanicolide E (1) and javanicolide F (2), along with fifteen known C-20 quassinoids were isolated from the seeds of Brucea javanica (L.) Merr. The antitobacco mosaic virus (TMV) activity of these quassinoids was screened by the conventional half-leaf and leaf-disk method along with Western blot analysis. All of the seventeen quassinoids showed potent anti-TMV activity. Among them, eight compounds, brusatol (3), bruceine B (4), bruceoslde B (5), yadanzioside I (6), yadanzioside L (7), bruceine D (8), yadanziolide A (9), and aglycone of yadanziolide D (17), showed strong antiviral activities, with IC_(50) values in the range of 3.42-5.66 μM, and were much more effective than the positive control, ningnanmycin (IC_(50) = 117.3 μM). The antiviral structure-activity relationships of quassinoids against TMV were also discussed.

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[1]Tobacco Mosaic Virus (TMV) Inhibitors from Picrasma quassioides Benn. Chen, Jia,Yan, Xiao-Hui,Fang, Xin,Di, Ying-Tong,Hao, Xiao-Jiang,Chen, Jia,Yan, Xiao-Hui,Dong, Jia-Hong,Sang, Peng,Zhang, Zhong-Kai,Dong, Jia-Hong,Sang, Peng,Zhang, Zhong-Kai.

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