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Aconitum Diterpenoid Alkaloid Profiling to Distinguish between the Official Traditional Chinese Medicine (TCM) Fuzi and Adulterant Species Using LC-qToF-MS with Chemometrics

文献类型： 外文期刊

作者： Shi, Yana 1 ; Zhao, Yi 3 ; Qian, Junxiang 2 ; Dong, Zhiyuan 2 ; Wen, Guosong 1 ; Zhao, Dake 5 ; Kennelly, Edward J. 3 ;

作者机构： 1.Yunnan Agr Univ, Coll Agr & Biotechnol, Kunming 650201, Yunnan, Peoples R China

2.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650201, Yunnan, Peoples R China

3.CUNY, Dept Biol Sci, Lehman Coll, Bronx, NY 10468 USA

4.CUNY, Grad Ctr, PhD Program Biol, New York, NY 10016 USA

5.Yunnan Univ, Biocontrol Engn Res Ctr Crop Dis & Pest, Kunming 650405, Yunnan, Peoples R China

6.Yunnan Univ, Sch Ecol & Environm Sci, Kunming 650405, Yunnan, Peoples R China

7.CUNY, Grad Ctr, PhD Programs Biochem Biol & Chem, New York, NY 10016 USA

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.779； 五年影响因子：3.989 ）

ISSN： 0163-3864

年卷期： 2021 年 84 卷 3 期

页码：

收录情况： SCI

摘要： The lateral roots of Aconitum carmichaelii, known in Chinese as fuzi, are officially recognized as a materia medica in the Chinese Pharmacopoeia and used culinarily to prepare herbal soups. A strategy combining UPLC-qToF-MS analysis of A. carmichaelii and its intraspecies and interspecies chemometrics study was developed to examine the distribution of Aconitum marker metabolites. Four diterpenoid alkaloids were recognized to be important markers in fuzi, and another 15 markers were identified to differentiate A. carmichaelii from adulterant species. The detected fuzi markers, mesaconitine (47) and hypaconitine (51), are known to be the principal toxins in this herb, while fuziline (6) and benzoylmesaconine (25) are associated with its medicinal properties. Additional marker compounds have been detected in other Aconitum species that are useful for identifying adulteration. This study provides a useful resource for detecting traditional Chinese medicine (TCM) adulterants and assisting in the quality control of botanical products in TCM and beyond.

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