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Identification, Biological Activities and Biosynthetic Pathway of Dendrobium Alkaloids

文献类型： 外文期刊

作者： Mou, Zongmin 1 ; Zhao, Yi 2 ; Ye, Fei 5 ; Shi, Yana 6 ; Kennelly, Edward J. 2 ; Chen, Suiyun 1 ; Zhao, Dake 1 ;

作者机构： 1.Yunnan Univ, Sch Ecol & Environm Sci, Biocontrol Engn Res Ctr Crop Dis & Pest, Kunming, Yunnan, Peoples R China

2.CUNY, Dept Biol Sci, Lehman Coll, Bronx, NY USA

3.CUNY, Grad Ctr, Bronx, NY USA

4.CUNY, Grad Ctr, PhD Programs Biochem Biol & Chem, Bronx, NY USA

5.Kunming Municipal Hosp Tradit Chinese Med, Kunming, Yunnan, Peoples R China

6.Yunnan Agr Univ, Coll Agr & Biotechnol, Kunming, Yunnan, Peoples R China

7.Yunnan Acad Agr Sci, Inst Med Plants, Kunming, Yunnan, Peoples R China

关键词： alkaloids; orchidaceae; Dendrobium; anti-inflammatory; antitumor; mechanisms; biosynthetic pathway

期刊名称：FRONTIERS IN PHARMACOLOGY （ 影响因子：4.225； 五年影响因子：4.604 ）

ISSN： 1663-9812

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： Dendrobium is a genus of flowering plants belonging to the Orchidaceae family with more than 1,400 species. Many Dendrobium species have been used as medicinal plants in several Asian countries for thousands of years. Alkaloids were reported as the major biological markers due to their complex chemical compositions and various types. In this review, we summarized the structural types of alkaloids, their pharmacological activities, as well as the mechanisms of biological activities. More than sixty alkaloids were isolated and identified from the Dendrobium genus. Moreover, the pharmacological effects of Dendrobium alkaloids as hepatic lipid and gluconeogenesis regulation, as neuroprotection, and as anti-tumor, anti-inflammatory, anti-diabetes, and anti-virus factors were described. Besides, the total chemical synthesis of dendrobine is provided, while the biosynthetic pathway of dendrobine has been proposed based on the functions of associated genes. For applications of these invaluable herbs, more researches on the extraction of biological markers from compounds are needed. Further confirmation of the proposed biosynthetic pathways is anticipated as well.

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