New azaphilones from Penicillium variabile, a fungal endophyte from roots of Aconitum vilmorinianum
文献类型： 外文期刊
作者： Shao, Yating 1 ; Yan, Hui 3 ; Yin, Tianpeng 4 ; Sun, Zhongwen 1 ; Xie, Huiding 1 ; Song, Liudong 1 ; Sun, Kongchun 1 ; Li 1 ;
作者机构： 1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming, Yunnan, Peoples R China
2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming, Yunnan, Peoples R China
3.Yunnan Acad Agr Sci, Inst Agr Environm & Resources, Beijing Rd 2238, Kunming, Yunnan, Peoples R China
4.Zunyi Med Univ, Zhuhai Key Lab Fundamental & Appl Res Tradit Chin, Zhuhai Campus, Zhuhai, Peoples R China
期刊名称：JOURNAL OF ANTIBIOTICS （ 影响因子：2.649； 五年影响因子：2.772 ）
ISSN： 0021-8820
年卷期： 2020 年 73 卷 2 期
页码：
收录情况： SCI
摘要： Two new azaphilone derivatives, comazaphilones G and H (1 and 2), together with eight known analogues (3-10), were isolated from an endophytic fungus Penicillium variabile. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1, 2 and 4-10 were tested their nitric oxide inhibitory activities in lipopolysaccharide-activated RAW 264.7 macrophage cells. Compounds 1, 2 and 4-9 showed significant nitric oxide inhibitory activities with IC50 values ranged from 4.35 +/- 0.05 to 40.52 +/- 0.47 mu M.
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