Lactobacillus helveticus LZ-R-5 Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function
文献类型： 外文期刊
作者： Zhao, Xiaogan 1 ; Lin, Tao 1 ; Jiang, Wenkai 1 ; Lin, Yihan 3 ; Xiao, Luyao 1 ; Tian, Yufang 1 ; Ma, Kai 4 ; Zhang, Changliang 4 ; Ji, Feng 4 ; Mahsa, Ghahvechi Chaeipeima 1 ; Rui, Xin 1 ; Li, Wei 1 ;
作者机构： 1.Nanjing Agr Univ, Sanya Inst, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
2.Yunnan Acad Agr Sci, Qual Stand & Testing Technol Res Inst, Kunming 650205, Yunnan, Peoples R China
3.Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 301617, Peoples R China
4.Jiangsu New Bio Biotechnol Co Ltd, Jiangyin 214400, Jiangsu, Peoples R China
5.Jiangsu Biodep Biotechnol Co Ltd, Jiangyin 214400, Jiangsu, Peoples R China
关键词： kefir; Lactobacillus helveticus; ulcerativecolitis; short-chain fatty acid; gut microbiota
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2025 年 73 卷 1 期
页码：
收录情况： SCI
摘要： Lactobacillus helveticus LZ-R-5 (R-5), a strain with high epithelial adhesion and bioactive exopolysaccharide production, was isolated from Tibetan kefir grains. This study investigated its potential to alleviate intestinal inflammation using a DSS-induced colitis model in BALB/c mice. We integrated microbial diversity and serological analyses to assess changes in gut flora and cytokines following the R-5 treatment. Pathological assessments showed that R-5 reduced crypt distortion in the proximal colon and mitigated hepatic immune challenges by enhancing gut barrier function. The increased relative expression of TGF-beta 1 and the downregulation of NLRP3-related inflammatory factors were conducive to preventing organ damage in the thymus and spleen of mice with colitis. Additionally, R-5 stimulated GPR43 expression and improved epithelial nutrition, promoting mucin production to prevent enterotoxin leakage. It also modulated the gut microbiota by suppressing Bacteroides and Erysipelatoclostridium, leading to a microbiota composition more akin to that of normal flora.
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