Amelioration of Kluyveromyces marxianus GY-8 on high-fat diet-induced obesity and gut microbiota dysbiosis
文献类型： 外文期刊
作者： Tang, Nanyu 1 ; Zhao, Xiaogan 1 ; Lin, Tao 2 ; Lin, Yihan 3 ; Xu, Chang 4 ; Ma, Kai 5 ; Zhang, Changliang 5 ; Ji, Feng 5 ; Mahsa, Ghahvechi Chaeipeima 1 ; Xiao, Luyao 1 ; Rui, Xin 1 ; Li, Wei 1 ;
作者机构： 1.Sanya Inst Nanjing Agr Univ, Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
2.Yunnan Acad Agr Sci, Kunming 650205, Yunnan, Peoples R China
3.Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 301617, Peoples R China
4.Hunan Univ Tradit Chinese Med, Coll Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China
5.Jiangsu New Biobiotechnol Co Ltd, Jiangyin 214400, Jiangsu, Peoples R China
6.Jiangsu Biodep Biotechnol Co Ltd, Jiangyin 214400, Jiangsu, Peoples R China
关键词： Diet-induced obesity; Gut microbiota; Probiotic; Short-chain fatty acid; Kluyveromyces marxianus
期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）
ISSN： 2212-4292
年卷期： 2025 年 68 卷
页码：
收录情况： SCI
摘要： The rising prevalence of diet-induced obesity underscores the need for novel interventions targeting metabolic dysregulation and gut microbiota imbalance. The aim of this study was to evaluate the intervention effect of the potential probiotic Kluyveromyces marxianus GY-8 isolated from Tibetan kefir on obesity. This strain demonstrated notable lipid-lowering ability in vitro, exhibiting a cholesterol assimilation rate of 50.97 % and triglyceride degradation rate of 42.30 %. Further, K. marxianus GY-8 was administered orally to high-fat diet-induced obese mice to assess its intervention effects. The results suggested that K. marxianus GY-8 treatment significantly reduced body weight, improved the hepatic lipid accumulation and decreased liver damage by reducing heptic triglyceride (TG), total cholesterol (TC), and malondialdehyde (MDA) levels. Moreover, K. marxianus GY-8 treatment downregulated expression of carnitine palmitoyl transferase-1 (CPT1), sterol regulatory element binding protein-1c (SREBP-1c), and acetyl-CoA carboxylases alpha (ACACA), thereby improving hepatic lipid metabolism. In addition, K. marxianus GY-8 treatment modulated the dysbiotic gut microbiota, by enriching taxa associated with short-chain fatty acids (SCFAs) production, particularly propionic and butyric acid, which correlated with ameliorated metabolic dysfunction. Therefore, it can be concluded that K. marxianus GY-8 alleviates obesity through the dual mechanisms of regulating heptic lipid metabolism and restoration of gut microbiota balance. These findings may provide theoretical basis for the application of K. marxianus GY-8 in the development of anti-obesity related functional foods.
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