Natural Geranylated Sulfur-Containing Amides with Inhibitory Effect on Th17 Differentiation
文献类型： 外文期刊
作者： Ji, Kai-Long 1 ; Tang, Yan-Qing 2 ; Guo, Zheng-Yang 2 ; GongPan, Pian-Chou 1 ; Sun, Peng 1 ; Lu, Jian-Mei 1 ; Dai, Meng-Yuan 3 ; Li, Ting 2 ;
作者机构： 1.Chinese Acad Sci, CAS Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Kunming 650223, Peoples R China
2.Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China
3.Yunnan Acad Agr Sci, Ind Crop Res Inst, Kunming 650223, Peoples R China
关键词： Glycosmis lucida; geranylated sulfonyl amides; glylucidamides; Th17 differentiation; ROR gamma t
期刊名称：CHEMISTRY & BIODIVERSITY （ 影响因子：2.9； 五年影响因子：2.8 ）
ISSN： 1612-1872
年卷期： 2023 年 20 卷 6 期
页码：
收录情况： SCI
摘要： Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds (1-10), including two previously unreported geranylated sulfurcontaining amides (1 and 2) and eight known ones (3-10). Structural characterization was carried out using comprehensive spectroscopic methods including NMR, MS and CD. The inhibitory effects of all isolates on Th17 differentiation were evaluated, of which compounds 1 and 6 significantly inhibited Th17 differentiation with IC50 values of 0.36 and 1.30 mu M, respectively, while both 1 and 6 failed to bind to retinoic acid-related orphan receptor gamma t (ROR gamma t), suggesting that their inhibition of Th17 differentiation is independent of ROR gamma t.
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