Indole diterpenoids from the endophytic fungus Drechmeria sp as natural antimicrobial agents
文献类型： 外文期刊
作者： Zhao, Jian-Chao 1 ; Wang, Ya-Li 1 ; Zhang, Tian-Yuan 1 ; Chen, Zhong-Jian 3 ; Yang, Tian-Mei 4 ; Wu, Ying-Ying 1 ; Sun 1 ;
作者机构： 1.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Wenhua Rd 103, Shenyang 110016, Liaoning, Peoples R China
2.Dalian Med Univ, Coll Pharm, Coll Inst Integrat Med, Dalian 116044, Peoples R China
3.Wenshan Univ, Wenshan Sanqi Res Inst, Wenshan 663000, Peoples R China
4.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650200, Yunnan, Peoples R China
关键词： Drechmeria sp.; Indole diterpenoids; Theoretical calculation; Antimicrobial activity
期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）
ISSN： 0031-9422
年卷期： 2018 年 148 卷
页码：
收录情况： SCI
摘要： A fungal strain, Drechmeria sp., was isolated from the root of Panax notoginseng. Totally, seven new indole diterpenoids, drechmerins A-G (1-7), were isolated from the fermentation broth of Drechmeria sp. together with four known analogues (8-11). Their structures were determined on the basis of 1D and 2D NMR and electronic circular dichroism (ECD) spectroscopic analyses as well as theoretical calculations. All the isolated compounds were evaluated for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin B (2) displayed antimicrobial activity against C. albicans with an MIC value of 12.5 mu g/mL. Molecular docking was used to investigate interactions of peptide deformylase with compounds 1-3, 5-7, 9, and 10. (C) 2018 Elsevier Ltd. All rights reserved.
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