An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity
文献类型： 外文期刊
作者： Liang, Jia-Hao 1 ; Huo, Xiao-Kui 1 ; Cheng, Zhong-Bin 3 ; Sun, Cheng-Peng 1 ; Zhao, Jian-Chao 2 ; Kang, Xiao-Hui 1 ; Z 1 ;
作者机构： 1.Dalian Med Univ, Coll Pharm, Coll Inst Integrat Med, Natl & Local Joint Engn Res Ctr Drug Dev Neurodeg, Dalian, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang, Liaoning, Peoples R China
3.Henan Univ, Pharmaceut Coll, Kaifeng, Peoples R China
4.Wenshan Univ, Wenshan Sanqi Res Inst, Wenshan, Peoples R China
5.Yunnan Acad Agr Sci, Inst Med Plants, Kunming, Yunnan, Peoples R China
6.Dalian Maternal & Child Care Hlth Hosp, Dalian, Peoples R China
关键词： Drechmeria sp; indole diterpenoid; antimicrobial activity; molecular docking
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
ISSN： 1478-6419
年卷期： 2019 年 33 卷 19 期
页码：
收录情况： SCI
摘要： One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 mu g/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking.
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