Stellera chamaejasme and Its Main Compound Luteolin 7-O-Glucoside Alleviates Skin Lesions in Oxazolone- and 2,4-Dinitrochlorobenzene-Stimulated Murine Models of Atopic Dermatitis
文献类型： 外文期刊
作者： Jo, Beom-Geun 1 ; Park, No-June 2 ; Jegal, Jonghwan 1 ; Choi, Sangho 3 ; Lee, Sang Woo 3 ; Yi, Li Wan 4 ; Kim, Su-Nam; 1 ;
作者机构： 1.Pusan Natl Univ, Coll Pharm, 63 Beon Gil 2, Busan 46241, South Korea
2.Korea Inst Sci & Technol, Nat Prod Res Inst, 679 Saimdang Ro, Kangnung 25451, South Korea
3.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon, South Korea
4.Yunnan Acad Agr Sci, Inst Med Plants, Kunming, Yunnan, Peoples R China
关键词： Stellera chamaejasme; Thymelaeaceae; luteolin 7-O-glucoside; atopic dermatitis; skin barrier function; interleukin 4; immunoglobulin E
期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）
ISSN： 0032-0943
年卷期： 2019 年 85 卷 7 期
页码：
收录情况： SCI
摘要： Stellera chamaejasme, also known as "Langdu", has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic dermatitis in oxazolone-treated BALB/c mice and 2,4-dinitrochlorobenzene-treated hairless mice. The epicutaneous applications of oxazolone and 2,4-dinitrochlorobenzene evoke an experimental murine atopic dermatitis-like reaction in BALB/c mouse ears and SKH-1 hairless mice. Atopic skin symptoms, including erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and lichenification (skin thickening), responded to treatment with S. chamaejasme aerial parts EtOH extract for 2 or 3 weeks. Histopathological examination revealed S. chamaejasme aerial parts EtOH extract significantly reduced inflammatory cell infiltration when applied to atopic dermatitis mice. In addition, luteolin 7-O-glucoside, the major active compound of the S. chamaejasme aerial parts EtOH extract, decreased serum IgE and IL-4 levels and transepidermal water loss and increased skin hydration, therefore exhibiting strong anti-atopic dermatitis activity in 2,4-dinitrochlorobenzene-induced atopic dermatitis mice. In this study, we confirmed antipruritic and antidermatitic effects of S. chamaejasme extract and its main component luteolin 7-O-glucoside in atopic dermatitis murinemodels. The study shows S. chamaejasme aerial parts EtOH extract and luteolin 7-O-glucoside are most likely to be potential drug candidates for atopic dermatitis treatment.
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