Anti-Inflammatory and Photoaging-Protective Effects of Olea europaea through Inhibition of AP-1 and NF-kappa B Pathways
文献类型： 外文期刊
作者： Song, Chaoran 1 ; Jeong, Deok 1 ; Hong, Yo Han 1 ; Li, Wan Yi 3 ; Lee, Sang Woo 4 ; Hossain, Mohammad Amjad 5 ; Taamal 1 ;
作者机构： 1.Sungkyunkwan Univ, Dept Integrat Biotechnol, 2066 Seobu Ro, Suwon 16419, South Korea
2.Sungkyunkwan Univ, Biomed Inst Convergence SKKU BICS, Suwon 16419, South Korea
3.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650205, Yunnan, Peoples R China
4.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, South Korea
5.Chonbuk Natl Univ, Coll Vet Med, Iksan 54596, South Korea
6.Ctr Biotechnol Technopole Borj Cedria, Lab Olive Biotechnol, BP 901, Hammam Lif 2050, Tunisia
7.Univ Hafr Al Batin, Dept Chem, Hafar al Batin 31991, Saudi Arabia
关键词： Olea europaea; Antiphotoaging Effect; Anti-Inflammatory Effect; AP-1; NF-kappa B
期刊名称：AMERICAN JOURNAL OF CHINESE MEDICINE （ 影响因子：4.667； 五年影响因子：4.135 ）
ISSN： 0192-415X
年卷期： 2020 年 48 卷 8 期
页码：
收录情况： SCI
摘要： Olea europaea is a beneficial edible plant with a number of biological activities like anti-inflammatory, anti-oxidant, antithrombic, antihyperglycemic, and anti-ischemic activities. The mechanisms behind the antiphotoaging and anti-inflammatory effects of Olea europaea are not fully understood. To investigate how an ethanol extract of Olea europaea (Oe-EE) exerts these effects, we explored its activities in human keratinocytes and dermal fibroblasts. We assessed the anti-oxidant effects of Oe-EE via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assays and measured the expression levels of matrix metalloproteinases (MMPs), cyclooxygenase-2, interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and moisturizing factors. Antiphotoaging and anti-inflammatory mechanisms of Oe-EE were explored by assessing signaling molecule activation via immunoblotting. Oe-EE treatment decreased the mRNA expression level of MMPs, cyclooxygenase-2, IL-6, and TNF-alpha and restored type I collagen, filaggrin, and sirtuin 1 expression in UVB-irradiated cells. Furthermore, Oe-EE inhibited the activities of several activator protein 1 regulatory enzymes, including extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), and inhibited nuclear factor (NF)-kappa B pathway signaling proteins. Therefore, our results indicate that Oe-EE has photoaging-protective and anti-inflammatory effects.
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