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Sorbaria kirilowii Ethanol Extract Exerts Anti-Inflammatory Effects In Vitro and In Vivo by Targeting Src/Nuclear Factor (NF)-kappa B

文献类型： 外文期刊

作者： Jang, Jiwon 1 ; Lee, Jong Sub 4 ; Jang, Young-Jin 5 ; Choung, Eui Su 4 ; Li, Wan Yi 6 ; Lee, Sang Woo 7 ; Kim, Eunji 1 ;

作者机构： 1.Sungkyunkwan Univ, Dept Integrat Biotechnol, Suwon 16419, South Korea

2.Sungkyunkwan Univ, Res Inst Biomol Control, Suwon 16419, South Korea

3.Sungkyunkwan Univ, Biomed Inst Convergence SKKU BICS, Suwon 16419, South Korea

4.DanjoungBio Co Ltd, Wonju 26303, South Korea

5.Chonbuk Natl Univ, Coll Vet Med, Iksan 54596, South Korea

6.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650224, Yunnan, Peoples R China

7.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, South Korea

关键词： Sorbaria kirilowii; anti-inflammatory effect; NF-kappa B signaling pathway; IKK alpha/beta Src

期刊名称：BIOMOLECULES （ 影响因子：4.879； 五年影响因子：5.362 ）

ISSN：

年卷期： 2020 年 10 卷 5 期

页码：

收录情况： SCI

摘要： Inflammation is a fundamental process for defending against foreign antigens that involves various transcriptional regulatory processes as well as molecular signaling pathways. Despite its protective roles in the human body, the activation of inflammation may also convey various diseases including autoimmune disease and cancer. Sorbaria kirilowii is a plant originating from Asia, with no anti-inflammatory activity reported. In this paper, we discovered an anti-inflammatory effect of S. kirilowii ethanol extract (Sk-EE) both in vivo and in vitro. In vitro effects of Sk-EE were determined with lipopolysaccharide (LPS)-stimulated RAW264.7 cells, while ex vivo analysis was performed using peritoneal macrophages of thioglycollate (TG)-induced mice. Sk-EE significantly reduced the nitric oxide (NO) production of induced macrophages and inhibited the expression of inflammation-related cytokines and the activation of transcription factors. Moreover, treatment with Sk-EE also decreased the activation of proteins involved in nuclear factor (NF)-kappa B signaling cascade; among them, Src was a prime target of Sk-EE. For in vivo assessment of the anti-inflammatory effect of Sk-EE, HCl/EtOH was given by the oral route to mice for gastritis induction. Sk-EE injection dose-dependently reduced the inflammatory lesion area of the stomach in gastritis-induced mice. Taking these results together, Sk-EE exerts its anti-inflammatory activity by regulating intracellular NF-kappa B signaling pathways and also shows an authentic effect on reducing gastric inflammation.

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