Theabrownin ameliorated lipid accumulation via modulating circadian rhythms in oleic acid-induced HepG2 cells
文献类型： 外文期刊
作者： Zhao, Chunyan 1 ; Zhao, Lei 1 ; Li, Zelin 1 ; Miao, Yue 4 ; Lei, Shuwen 1 ; Shan, Bo 1 ; Wang, Qiuping 1 ; Tan, Chao 1 ; Peng, Chunxiu 3 ; Gong, Jiashun 1 ;
作者机构： 1.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China
2.Yunnan Acad Agr Sci, Agroprod Proc Res Inst, Kunming 650221, Peoples R China
3.Yunnan Agr Univ, Coll Hort & Landscape, Kunming 650201, Yunnan, Peoples R China
4.Yunnan Acad Agr Sci, Med Plants Res Inst, Kunming 650201, Yunnan, Peoples R China
关键词： Pu-erh tea; Theabrownin; Circadian rhythms; Lipid accumulation; Proteomics; siRNA; HepG2 cells
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：3.8； 五年影响因子：4.6 ）
ISSN： 1756-4646
年卷期： 2024 年 116 卷
页码：
收录情况： SCI
摘要： Theabrownin (TB) is the main characteristic component and bioactive substance of Pu-erh tea. Our previous studies have demonstrated interactions among the TB, the circadian rhythm, and obesity, but the underlying mechanism remains unclear. In this study, we focused on the mechanism by which TB ameliorates lipid accumulation caused by oleic acid (OA) by modulating circadian rhythm genes in HepG2 cells. The results showed that TB could reduce triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL-C) levels, reactive oxygen species (ROS) overproduction and lipid droplet formation. Additionally, TB could regulate OAmediated circadian desynchrony by regulating the mRNA and protein expression of circadian genes. Furthermore, as revealed by proteomics results, the PPAR pathway is a potential pathway through which TB ameliorates lipid metabolism disorders. After Bmal1 knockdown, the ameliorative effect of TB on OA-induced PPAR gamma and plin1 protein expression was decreased, which suggested that TB could ameliorate lipid accumulation in HepG2 cells via a Bmal1-dependent pathway.
- 相关文献
作者其他论文 更多>>
-
Comparative analysis of drying characteristics, physicochemical properties and volatile flavor components of Dendrocalamus brandisii shoots under four drying techniques
作者：Wang, Hailang;Wu, Boxiao;Zhang, Min;Chen, Lin;Liu, Yun;Kan, Huan;Cao, Changwei;Li, Zelin;Li, Zhengtian
关键词：Bamboo shoots; Drying technology; Volatile organic components; Quality assessment; Energy consumption
-
Caffeine regulates both osteoclast and osteoblast differentiation via the AKT, NF-κB, and MAPK pathways
作者：Miao, Yue;Lei, Shuwen;Zhao, Chunyan;Wang, Qiuping;Tan, Chao;Gong, Jiashun;Miao, Yue;Zhao, Lei;Peng, Chunxiu;Gong, Jiashun
关键词：caffeine; osteoclasts; osteoblasts; bone metabolism; ovariectomy
-
Theabrownin from Pu-erh Tea Improves DSS-Induced Colitis via Restoring Gut Homeostasis and Inhibiting TLR2&4 Signaling Pathway
作者：Zhao, Lei;Zhao, Chunyan;Miao, Yue;Lei, Shuwen;Li, Yujing;Gong, Jiashun;Zhao, Lei;Miao, Yue;Gong, Jiashun;Peng, Chunxiu
关键词：Ulcerative colitis; Intestinal barrier; Differentiation of CD4+T cells; Intestinal microbiota
-
Effect of different agricultural conditions, practices, and processing on levels of total arsenic and species in cereals and vegetables: A review
作者：Liu, Yanfang;Huang, Yatao;Li, Lin;Xiong, Yangyang;Tong, Litao;Wang, Fengzhong;Fan, Bei;Gong, Jiashun;Gong, Jiashun
关键词：Arsenic; Species; Arsenic concentration; Processing methods; Cooking methods; Agricultural products
-
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway
作者：Zhao, Lei;Miao, Yue;Shan, Bo;Zhao, Chunyan;Gong, Jiashun;Zhao, Lei;Peng, Chunxiu;Gong, Jiashun
关键词：theabrownin; RAW264.7 macrophages; innate immune enhancement; anti-inflammatory effect; TLR2/4; NF-kappa B/MAPK/PI3K-AKT signaling pathways
-
Arsenic source analysis of rice from different growing environments and health risk assessment in Hunan Province, China
作者：Liu, Yanfang;Gong, Jiashun;Liu, Yanfang;Huang, Yatao;Li, Lin;Xiong, Yangyang;Wang, Xinrui;Tong, Litao;Wang, Fengzhong;Fan, Bei;Liu, Yanfang;Huang, Yatao;Li, Lin;Xiong, Yangyang;Wang, Xinrui;Tong, Litao;Wang, Fengzhong;Fan, Bei;Gong, Jiashun
关键词：Rice; Inorganic arsenic; Health risk assessment; ICP-MS; HPLC-HG-AFS; Irrigation water; Soil; Hunan Province
-
Effects of Different Probiotics on the Volatile Components of Fermented Coffee Were Analyzed Based on Headspace-Gas Chromatography-Ion Mobility Spectrometry
作者：Zhao, Linfen;Wang, Yanhua;Wang, Dongyu;He, Zejuan;Tan, Chao;Gong, Jiashun
关键词：coffee; probiotics; fermentation; aroma; headspace-gas chromatography-ion mobility spectrometry
