Identification authenticity Tibet snow tea of Lichen Thamnolia spp. using untargeted, pseudotargeted metabolomics and mock dock interacted with Alzheimer's disease
文献类型： 外文期刊
作者： Ye, Ying 1 ; Zhang, Jiao 1 ; Lin, Tao 1 ; Wu, Chaotong 2 ; Cao, Qiue 2 ; Liu, Hongcheng 1 ;
作者机构： 1.Yunnan Acad Agr Sci, Inst Qual Stand & Testing Technol, Agr Prod Qual Supervis & Inspection Ctr, Minist Agr, Kunming 650223, Yunnan, Peoples R China
2.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650000, Peoples R China
关键词： Authenticity identification; Tibet snow tea; High resolution mass spectrometry; Chemometric analysis
期刊名称：FITOTERAPIA （ 影响因子：2.6； 五年影响因子：3.0 ）
ISSN： 0367-326X
年卷期： 2025 年 184 卷
页码：
收录情况： SCI
摘要： A method was developed to authenticate Tibet snow tea (Lichen Thamnolia spp.) by UV fluorescence and high resolution mass spectrometry with chemometrics analysis. The representative snow teas were collected from Shannan in Tibet Autonomous Region. Tibet snow teas can be discriminated by the high resolution mass spectrometry (HRMS) with statistical methods. Total flavonoids were founded including 4 mono-nuclear phenols, 3 depsides and 3 depsidones. There was a good correlation between the antioxidant activity and the total phenols and total flavonoids, as indicated by the correlation coefficient. Three biomarkers were semi-quantitatively analyzed by targeted metabolomics and presumed to interact with Alzheimer's disease through molecular docking, suggesting that they are the primary active components of Tibet snow tea in treating Alzheimer's disease.
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