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Estrogenic properties of Prunus cerasoides extract and its constituents in MCF-7 cell and evaluation in estrogen-deprived rodent models

文献类型： 外文期刊

作者： Kim, So-Dam 1 ; Kim, Yeojin 1 ; Kim, Mingee 1 ; Jeong, Hyesoo 2 ; Choi, Sang Ho 3 ; Ryu, Hyung Won 4 ; Oh, Sei-Ryang 4 ;

作者机构： 1.Sookmyung Womens Univ, Drug Informat Res Inst, Coll Pharm, Seoul 04310, South Korea

2.Sookmyung Womens Univ, Coll Sci, Dept Biol Sci, Seoul, South Korea

3.KRIBB, Int Biol Mat Res Ctr, Daejeon, South Korea

4.KRIBB, Nat Med Res Ctr, Chungbuk, South Korea

5.Yunnan Acad Agr Sci, Inst Med Plants, Kunming, Yunnan, Peoples R China

6.Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin Key Lab Chem & Anal Tradit Chinese Med, Tianjin, Peoples R China

7.Tulane Univ, Sch Med, Dept Neurosurg & Neurol, Clin Neurosci Res Ctr, 1430 Tulane Ave, New Orleans, LA 70112 USA

关键词： ERE transcription; estrogen receptor; Prunus cerasoides; phytoestrogen; triglyceride

期刊名称：PHYTOTHERAPY RESEARCH （ 影响因子：5.878； 五年影响因子：5.286 ）

ISSN： 0951-418X

年卷期：

页码：

收录情况： SCI

摘要： Prunus cerasoides (PC) products contain relatively high levels of flavones and isoflavones and may be potential sources of phytoestrogens for postmenopausal symptom relief. We assessed the PC extract (PCE) and its representative constituents in vitro with assays for estrogen receptor alpha binding, estrogen response element transcriptional activity, cell proliferation, and gene expression changes for pS2 in MCF-7 cells. PCE and its compounds showed strong estrogen receptor binding affinities and estrogen response element induction. A previously undescribed compound (designated as compound 18), now identified as being gentisic acid, 5-O-beta-D-(6'-O-trans-4-coumaroyl)-glucopyranoside, also showed potent estrogenic properties and induced proliferation of MCF-7 cells. PCE was evaluated for its in vivo uterotrophic effects in immature female rats as well as for its lipid lowering effects in estrogen-deprived animals. For ovariectomized rats and aged female mice, PCE-treated groups had lower plasma triglyceride levels compared with control and, for the same comparison, had reduced serum levels of liver stress/damage markers. Our results point to strong estrogenic activities and beneficial metabolic effects for PCE, with properties that put PC and its extracts as promising sources of phytoestrogens for symptom relief in menopausal and postmenopausal cases.

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