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A new flavonoid from Stellera chamaejasme L., stechamone, alleviated 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in a murine model

文献类型： 外文期刊

作者： Jo, Beom-Geun 1 ; Park, No-June 2 ; Jegal, Jonghwan 1 ; Choi, Sangho 3 ; Lee, Sang Woo 3 ; Jin, Hang 4 ; Kim, Su-Nam 2 ;

作者机构： 1.Pusan Natl Univ, Coll Pharm, Busan 46241, South Korea

2.Korea Inst Sci & Technol, Nat Prod Res Inst, Kangnung 25451, South Korea

3.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, South Korea

4.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650205, Yunnan, Peoples R China

关键词： Stellera chamaejasme L.; Stechamone; Atopic dermatitis; 2,4-Dinitrochlorobenzene; Skin barrier function; Interleukin 4

期刊名称：INTERNATIONAL IMMUNOPHARMACOLOGY （ 影响因子：4.932； 五年影响因子：4.624 ）

ISSN： 1567-5769

年卷期： 2018 年 59 卷

页码：

收录情况： SCI

摘要： Stellera chamaejasme L. (family Thymelaeaceae), also known as 'Langdu', has been traditionally used to treat of skin-related diseases, such as, psoriasis and skin ulcers. The aim of this study was to identify the biologically active component of S. chtunaejasme and evaluate its preventive effects on IL-4 and mast cell degranulation in RBL-2H3 cells and on the development of atopic dermatitis (AD) in 2,4-dinitrochlorobenzene (DNCB)-treated SKH-1 hairless mice. A novel flavonoid, genkwanin 5-O-xylosykl(1 -> 2))glucoside (named stechamone), and three known compounds (umbelliferone, luteolin, and luteolin-7-O-glucoside) were isolated from the aerial parts of S. chamaejasme using chromatographic methods. Of these four compounds, stechamone most potently inhibited IL-4 production and mast cell degranulation in RBL-2H3 cells. Topical application of 0.5% stechamone improved atopic skin symptoms, including, erythema (redness), pruritus (itching), exudation (weeping), excoriation (peeling), and licheniflcation (skin thickening) in DNCB-treated AD mice by accelerating skin barrier recovery function and suppressing inflammatory cell infiltration. In addition, stechamone attenuated DNCB-induced increases in IL-4 (an inflammatory T(H)2 cytokine) expression and in serum IgE levels in our murine model of AD. DNCB induced AD-like skin lesions, but treatment with stechamone exhibited strong anti-atopic activity by regulating skin barrier function and reducing inflammatory responses. The results obtained suggest stechamone is a potential anti-atopic agent and treatment for skin inflammatory diseases.

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