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Green synthesis and biological activities of silver nanoparticles prepared by Carpesium cernuum extract

文献类型： 外文期刊

作者： Ahn, Eun-Young 1 ; Jin, Hang 3 ; Park, Youmie 1 ;

作者机构： 1.Inje Univ, Coll Pharm, 197 Inje Ro, Gimhae 50834, Gyeongnam, South Korea

2.Inje Univ, Inje Inst Pharmaceut Sci & Res, 197 Inje Ro, Gimhae 50834, Gyeongnam, South Korea

3.YAAS, Inst Med Plants, 2238 Beijing Rd, Kunming 650205, Yunnan, Peoples R China

关键词： Silver nanoparticles; Carpesium cernuum; Green synthesis; Antioxidant activity; Cytotoxicity

期刊名称：ARCHIVES OF PHARMACAL RESEARCH （ 影响因子：4.946； 五年影响因子：3.483 ）

ISSN： 0253-6269

年卷期： 2019 年 42 卷 10 期

页码：

收录情况： SCI

摘要： The extract of Carpesium cernuum whole plant was successfully used as a green factory for the synthesis of silver nanoparticles in a one-step, one-pot process. The extract efficiently reduced silver ions to spherical silver nanoparticles. The size was measured as 13.0 +/- 0.2 nm from high resolution transmission electron microscopic images. The reaction yield was determined to be 99.6% using inductively coupled plasma optical emission spectroscopy. The silver nanoparticles were highly stable for 28 days at ambient temperature without forming agglomeration or aggregation of nanoparticles. Dose-dependent antioxidant activity of the silver nanoparticles was observed in terms of the scavenging activity of 2,2-diphenyl-1-picrylhydrazyl radicals. The silver nanoparticles also exerted cytotoxicity on Mus musculus skin melanoma cells (B16F10) and human lung cancer cells (A549) in a dose-dependent manner. Specifically, the cytotoxicity of the silver nanoparticles on A549 cells was closely associated with apoptotic cell death. Cellular uptake of the silver was evaluated via inductively coupled plasma mass spectrometry, and a higher percentage of silver was taken up by A549 cells (22.6%) than by B16F10 cells (17.3%). This result indicated that higher cellular uptake of silver nanoparticles resulted in higher cytotoxicity on A549 cells. Therefore, plant extracts are capable of being valuable natural sources for the green synthesis of silver nanoparticles that exhibit potent biological activities for pharmaceutical and biomedical applications in future nanomedicine.

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