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Quinolizidine Alkaloids with Antitomato Spotted Wilt Virus and Insecticidal Activities from the Seeds of Thermopsis lanceolata R. Br

文献类型: 外文期刊

作者: Hu, Zhan-Xing 1 ; Zhang, Peng 1 ; Zou, Ji-Bin 1 ; An, Qiao 1 ; Yi, Ping 1 ; Yuan, Chun-Mao 1 ; Zhang, Zhong-Kai 5 ; Zhao, Li-Hua 5 ; Hao, Xiao-Jiang 1 ;

作者机构: 1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China

2.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Peoples R China

3.Chinese Acad Sci, Guiyang 550002, Peoples R China

4.Guizhou Univ Tradit Chinese Med, Sch Pharm, Guiyang 550025, Peoples R China

5.Inst Biotechnol & Germplasm Resources, Yunnan Acad Agr Sci, Kunming 650204, Peoples R China

6.Chinese Acad Med Sci, Res Unit Chem Biol Nat Anti Virus Prod, Kunming 650201, Peoples R China

7.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Chi, Kunming Inst Bot, Kunming 650201, Peoples R China

关键词: against T. urticae. Thermopsis lanceolata R. Br.; quinolizidine alkaloids; anti-TSWV; insecticidal activity; structure-activity relationship

期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.895; 五年影响因子:6.048 )

ISSN: 0021-8561

年卷期:

页码:

收录情况: SCI

摘要: As part of our ongoing investigation of pesticide active quinolizidine alkaloids (QAs) from the family Fabaceae, the chemical constituents of the seeds of Thermopsis lanceolata R. Br. were systematically investigated. Bioassay-guided fractionation and purification of the crude extract led to the isolation of seventeen new QAs (1-17), including three new naturally occurring compounds (15-17), along with 15 known compounds (18-32). Their structures were elucidated by comprehensive spectroscopic data analysis (IR, UV, NMR, and HRESIMS) and quantum chemistry calculations (13C NMR and ECD). The antitomato spotted wilt virus activities and insecticidal activities against Aphis fabae, Nilaparvata lugens (Stal), and Tetranychus urticae of compounds 1- 32 were screened using the lesion counting method, spray method, and rice-stem dipping method, respectively. Biological tests indicated that compounds 6, 9, 10, and 18 displayed significant anti-TSWV activities compared with the positive control ningnanmycin. Compounds 3, 4, and 5 showed better insecticidal activities against A. fabae with LC50 values of 10.07, 12.07, and 6.56 mg/L, respectively. Moreover, compounds 5, 18, and 24 exhibited moderate insecticidal activities against N. lugens (Stal) with LC50 values of 37.91, 53.44, and 31.21 mg/L, respectively. Furthermore, compounds 9 and 10 exhibited moderate insecticidal activities against T. urticae.

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