文献类型： 外文期刊
作者： Shen, Yong 1 ; Liang, Wen-Juan 7 ; Shi, Ya-Na 1 ; Kennelly, Edward J. 9 ; Zhao, Da-Ke 2 ;
作者机构： 1.Yunnan Agr Univ, Coll Agron & Biotechnol, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Univ, Biocontral Engn Res Ctr Plant Dis & Pest, Kunming 650504, Yunnan, Peoples R China
3.Yunnan Univ, Biocontrol Engn Res Ctr Crop Dis & Pest, Kunming 650504, Yunnan, Peoples R China
4.Yunnan Univ, Sch Life Sci, Kunming 650504, Yunnan, Peoples R China
5.Kunming Kangren Biotechnol Co Ltd, Kunming 650203, Yunnan, Peoples R China
6.Yunnan Agr Univ, Res & Dev Ctr Funct Prod, Kunming 650201, Yunnan, Peoples R China
7.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Yunnan, Peoples R China
8.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650000, Yunnan, Peoples R China
9.CUNY, Dept Biol Sci, Lehman Coll, Bronx, NY 10468 USA
10.CUNY, PhD Programs Biochem Biol & Chem, Grad Ctr, New York, NY 10016 USA
期刊名称：NATURAL PRODUCT REPORTS （ 影响因子：13.423； 五年影响因子：13.566 ）
ISSN： 0265-0568
年卷期： 2020 年 37 卷 6 期
页码：
收录情况： SCI
摘要： Diterpenoid alkaloids, originating from the amination of natural tetracyclic diterpenes, are a diverse class of compounds having complex structural features with many stereocenters. The important pharmacological activities and structural complexity of the diterpenoid alkaloids have long interested scientists due to their medicinal uses, infamous toxicity, and unique biosynthesis. Since 2009, 373 diterpenoid alkaloids, assigned to 46 skeletons, have been isolated and identified from plants mostly in the Ranunculaceae family. The names, classes, molecular weight, molecular formula, NMR data, and plant sources of these diterpene alkaloids are collated here. This review will be a detailed update of the naturally occurring diterpene alkaloids reported from the plant kingdom from 2009-2018, providing an in-depth discussion of their diversity, biological activities, pharmacokinetics, toxicity, application, evolution, and biosynthesis.
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