Anti-Osteoporotic Effects of Combined Extract of Lycii Radicis Cortex and Achyranthes japonica in Osteoblast and Osteoclast Cells and Ovariectomized Mice
文献类型： 外文期刊
作者： Park, Eunkuk 1 ; Kim, Jeonghyun 1 ; Yeo, Subin 3 ; Lim, Eunguk 1 ; Choi, Chun Whan 4 ; Choi, Sangho 5 ; Li, Wan Yi 6 ; Lee, Ji-Won 7 ; Park, Jin-Hyok 8 ; Huh, Dam 8 ; Jeong, Seon-Yong 1 ;
作者机构： 1.Ajou Univ, Dept Med Genet, Sch Med, Suwon 16499, South Korea
2.Ajou Univ, Dept Biomed Sci, Grad Sch Med, Suwon 16499, South Korea
3.Nine B Co, Daejeon 34121, South Korea
4.Gyeonggi Inst Sci & Technol Promot, Nat Prod Res Inst, Suwon 16229, South Korea
5.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, South Korea
6.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650200, Yunnan, Peoples R China
7.Korea Food Res Inst, Seongnam 13539, Peoples R China
8.Dongwoodang Pharm Co Ltd, Yeongchen 38819, Peoples R China
关键词： Lycii Radicis Cortex; Achyranthes japonica; osteoporosis; ovariectomized mice; osteoblast; osteoclast
期刊名称：NUTRIENTS （ 影响因子：5.717； 五年影响因子：6.349 ）
ISSN：
年卷期： 2019 年 11 卷 11 期
页码：
收录情况： SCI
摘要： Osteoporosis is characterized by low bone density and quality with high risk of bone fracture. Here, we investigated anti-osteoporotic effects of natural plants (Lycii Radicis Cortex (LRC) and Achyranthes japonica (AJ)) in osteoblast and osteoclast cells in vitro and ovariectomized mice in vivo. Combined LRC and AJ enhanced osteoblast differentiation and mineralized bone-forming osteoblasts by the up-regulation of bone metabolic markers (Alpl, Runx2 and Bglap) in the osteoblastic cell line MC3T3-E1. However, LRC and AJ inhibited osteoclast differentiation of monocytes isolated from mouse bone marrow. In vivo experiments showed that treatment of LRC+AJ extract prevented OVX-induced trabecular bone loss and osteoclastogenesis in an osteoporotic animal model. These results suggest that LRC+AJ extract may be a good therapeutic agent for the treatment and prevention of osteoporotic bone loss.
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