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Phyllanacidins A-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities

文献类型: 外文期刊

作者: Geng, Hui-Chun 1 ; Zhu, Hong-Tao 1 ; Wang, Dong 1 ; Yang, Wei-Nong 4 ; Yang, Chong-Ren 1 ; Zhang, Ying-Jun 1 ;

作者机构: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

3.Yunnan Acad Agr Sci, Qual Standardizing & Testing Technol Inst, Kunming 650223, Yunnan, Peoples R China

4.Yunnan Xinxing Greening Engn Co, Kunming 650228, Yunnan, Peoples R China

关键词: Phyllanthus acidus; Cleistanthane diterpenoids; Cytotoxicity

期刊名称:FITOTERAPIA ( 影响因子:2.882; 五年影响因子:3.202 )

ISSN: 0367-326X

年卷期: 2021 年 148 卷

页码:

收录情况: SCI

摘要: Phytochemical investigation on the nonpolar extracts of P. acidus leaves afforded three new cleistanthane diterpenoids, named phyllanacidins A-C (1-3) 5 in addition to three known ones (4-6). Among them, compounds 2 and 3 represent the first examples of 17-nor cleistanthane diterpenoids. Their structures including absolute configurations were elucidated on the basis of extensive spectroscopic data and single crystal X-ray diffraction analysis. All the isolated cleistanthane diterpenoids were evaluated for their cytotoxic activities against five human cancer cell lines. Compounds 4-6 exhibited moderate cytotoxicity with IC50 values ranging from 16.11 to 30.82 mu M.

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