Phyllanacidins A-C, three new cleistanthane diterpenoids from Phyllanthus acidus and their cytotoxicities
文献类型： 外文期刊
作者： Geng, Hui-Chun 1 ; Zhu, Hong-Tao 1 ; Wang, Dong 1 ; Yang, Wei-Nong 4 ; Yang, Chong-Ren 1 ; Zhang, Ying-Jun 1 ;
作者机构： 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yunnan Acad Agr Sci, Qual Standardizing & Testing Technol Inst, Kunming 650223, Yunnan, Peoples R China
4.Yunnan Xinxing Greening Engn Co, Kunming 650228, Yunnan, Peoples R China
关键词： Phyllanthus acidus; Cleistanthane diterpenoids; Cytotoxicity
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2021 年 148 卷
页码：
收录情况： SCI
摘要： Phytochemical investigation on the nonpolar extracts of P. acidus leaves afforded three new cleistanthane diterpenoids, named phyllanacidins A-C (1-3) 5 in addition to three known ones (4-6). Among them, compounds 2 and 3 represent the first examples of 17-nor cleistanthane diterpenoids. Their structures including absolute configurations were elucidated on the basis of extensive spectroscopic data and single crystal X-ray diffraction analysis. All the isolated cleistanthane diterpenoids were evaluated for their cytotoxic activities against five human cancer cell lines. Compounds 4-6 exhibited moderate cytotoxicity with IC50 values ranging from 16.11 to 30.82 mu M.
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