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Macathioureas A-D, four new thiourea analogues from the roots of Lepidium meyenii

文献类型： 外文期刊

作者： Geng, Hui-Chun 1 ; Wang, Xue-Song 3 ; Chen, Ning 1 ; Lv, Jun-Jiang 1 ; Zhou, Min 1 ;

作者机构： 1.Yunnan Minzu Univ, Sch Ethn Med, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China

2.Yunnan Minzu Univ, Sch Ethn Med, Minist Educ, Kunming 650031, Peoples R China

3.Yunnan Acad Agr Sci, Inst Qual Stand & Testing Technol, Kunming 650223, Yunnan, Peoples R China

4.Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Chongqing 401331, Peoples R China

关键词： Lepidium meyenii; Thioureas; ECD; Cytotoxicity

期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）

ISSN： 0367-326X

年卷期： 2023 年 168 卷

页码：

收录情况： SCI

摘要： Macathioureas A-D (1-4), four new thiourea derivatives with a carbamothioylpyrrolidine-2-carboxamide framework, were isolated from the roots of Lepidium meyenii (Maca) collected from Qujing, Yunnan Province of China. Their structures were identified based on extensive spectroscopic data, including 1D NMR, 2D NMR, and HRESIMS techniques. Their absolute configurations were assigned as 7S by the comparison of the experi-mental and predicted electronic circular dichroism (ECD) spectra. All the thiourea analogues were tested for their cytotoxicities against five human cancer cell lines. However, no significant activities were detected at concen-trations up to 40 mu M.

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