Assessing the antioxidant, cytotoxic, apoptotic and wound healing properties of silver nanoparticles green-synthesized by plant extracts
文献类型： 外文期刊
作者： Ahn, Eun-Young 1 ; Jin, Hang 3 ; Park, Youmie 1 ;
作者机构： 1.Inje Univ, Coll Pharm, 197 Inje Ro, Gimhae 50834, Gyeongnam, South Korea
2.Inje Univ, Inje Inst Pharmaceut Sci & Res, 197 Inje Ro, Gimhae 50834, Gyeongnam, South Korea
3.Yunnan Acad Agr Sci, Inst Med Plants, 2238 Beijing Rd, Kunming 650205, Yunnan, Peoples R China
关键词： Silver nanoparticles; Plant extracts; Green synthesis; Antioxidant activity; Apoptosis; Cytotoxicity; Wound healing activity
期刊名称：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS （ 影响因子：7.328； 五年影响因子：6.654 ）
ISSN： 0928-4931
年卷期： 2019 年 101 卷
页码：
收录情况： SCI
摘要： We synthesized silver nanoparticles using thirty Chinese plant extracts via a green synthetic strategy. UV-visible spectra showed that the silver nanoparticles have an absorbance at 450 nm. Among the thirty extracts, seven extracts (Cratoxylum formosum, Phoebe lanceolate, Scurrula parasitica, Ceratostigma minus, Mucuna birdwoodiana, Myrsine africana and Lindera strychnifolia) exhibited the successful synthesis of silver nanoparticles. These seven extracts showed higher 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and reducing power than the other extracts. The silver nanoparticles synthesized using these seven extracts were mostly spherical with high colloidal stability. The cytotoxicity of these seven silver nanoparticle samples on human lung cancer cells (A549) was clearly higher than that of the extracts alone. Furthermore, the cytotoxicity was affected by the presence or absence of fetal bovine serum. Moreover, the cytotoxicity of the silver nanoparticles synthesized with Cratoxylum formosum and Mucuna birdwoodiana extracts resulted in apoptotic cell death in A549 cells. The wound healing activity observed by the cell scratch method on mouse fibroblast cells (NIH3T3) suggested that the Lindera strychnifolia extract produced silver nanoparticles with decent activity. These results provide ample and systematic information for researchers on the green synthesis of silver nanoparticles using plant extracts.
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