Isolation of maltol derivatives from Stellera chamaejasme and the anti-atopic properties of maltol on skin lesions in DNCB-stimulated mice
文献类型： 外文期刊
作者： Jo, Beom-Geun 1 ; Park, No-June 2 ; Kim, Su-Nam 2 ; Jegal, Jonghwan 1 ; Choi, Sangho 3 ; Lee, Sang Woo 3 ; Yi, Li Wan; 1 ;
作者机构： 1.Pusan Natl Univ, Coll Pharm, Busan 46241, South Korea
2.Korea Inst Sci & Technol, Nat Prod Res Inst, Kangnung 25451, South Korea
3.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, South Korea
4.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650205, Yunnan, Peoples R China
5.Sungkyunkwan Univ, Sch Pharm, Nat Prod Res Lab, Suwon 16419, South Korea
期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）
ISSN： 2046-2069
年卷期： 2019 年 9 卷 4 期
页码：
收录情况： SCI
摘要： The aim of this study was to isolate maltol derivatives from S. chamaejasme and to investigate the anti-atopic dermatitis (anti-AD) effect of maltol in a 2,4-dinitrochlorobenzene (DNCB)-sensitized mouse model of AD. A novel compound, maltol 3-O-(4'-O-cis-p-coumaroyl)-beta-D-glucoside (named isosoyamaloside I), and two known maltol derivatives (maltol and soyamaloside I) were isolated from S. chamaejasme using chromatographic methods. Dermal application of maltol to DNCB-sensitized AD mice reduced erythema, pruritus, and lichenification scores. Histopathological examinations revealed significant decline in mast cell infiltration in maltol-treated AD mice. In addition, maltol accelerated skin barrier recovery by reducing TEWL and skin pH and increasing skin hydration. Maltol was also found to suppress atopy-induced IL-4 and IgE elevations in serum, which are known to be essential for the development of atopy. The results of this study show that maltol is a potential therapeutic candidate for the treatment of AD-related skin diseases.
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