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Anti-Osteoporotic Effects of Kukoamine B Isolated from Lycii Radicis Cortex Extract on Osteoblast and Osteoclast Cells and Ovariectomized Osteoporosis Model Mice

文献类型： 外文期刊

作者： Park, Eunkuk 1 ; Kim, Jeonghyun 1 ; Kim, Mun-Chang 1 ; Yeo, Subin 1 ; Kim, Jieun 1 ; Park, Seulbi 1 ; Jo, Miran 1 ; Choi, 1 ;

作者机构： 1.Ajou Univ, Dept Med Genet, Sch Med, Suwon 16499, South Korea

2.Ajou Univ, Dept Biomed Sci, Grad Sch Med, Suwon 16499, South Korea

3.Gyeonggi Inst Sci & Technol Promot, Nat Prod Res Inst, Suwon 16229, South Korea

4.Hoseo Univ, Dept Biomed Lab Sci, Coll Life & Hlth Sci, Asan 31499, South Korea

5.Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, South Korea

6.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650200, Yunnan, Peoples R China

7.Korea Food Res Inst, Seongnam 13539, South Korea

8.Dongwoodang Pharm Co Ltd, Yeongchen 38819, South Korea

关键词： osteoporosis; herbal medicine; kukoamine B; osteoblast; osteoclast; bone mineral density; ovariectomized mice

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2019 年 20 卷 11 期

页码：

收录情况： SCI

摘要： Osteoporosis is an abnormal bone remodeling condition characterized by decreased bone density, which leads to high risks of fracture. Previous study has demonstrated that Lycii Radicis Cortex (LRC) extract inhibits bone loss in ovariectomized (OVX) mice by enhancing osteoblast differentiation. A bioactive compound, kukoamine B (KB), was identified from fractionation of an LRC extract as a candidate component responsible for an anti-osteoporotic effect. This study investigated the anti-osteoporotic effects of KB using in vitro and in vivo osteoporosis models. KB treatment significantly increased the osteoblastic differentiation and mineralized nodule formation of osteoblastic MC3T3-E1 cells, while it significantly decreased the osteoclast differentiation of primary-cultured monocytes derived from mouse bone marrow. The effects of KB on osteoblastic and osteoclastic differentiations under more physiological conditions were also examined. In the co-culture of MC3T3-E1 cells and monocytes, KB promoted osteoblast differentiation but did not affect osteoclast differentiation. In vivo experiments revealed that KB significantly inhibited OVX-induced bone mineral density loss and restored the impaired bone structural properties in osteoporosis model mice. These results suggest that KB may be a potential therapeutic candidate for the treatment of osteoporosis.

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